Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 383188..383783 Replicon chromosome
Accession NZ_CP054227
Organism Escherichia coli strain EcPF15

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag HR073_RS01805 Protein ID WP_000239581.1
Coordinates 383433..383783 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag HR073_RS01800 Protein ID WP_001223213.1
Coordinates 383188..383439 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HR073_RS01790 378853..382632 + 3780 WP_000060904.1 autotransporter assembly complex protein TamB -
HR073_RS01795 382635..382976 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
HR073_RS01800 383188..383439 + 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
HR073_RS01805 383433..383783 + 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
HR073_RS01810 383862..384392 - 531 WP_000055075.1 inorganic diphosphatase -
HR073_RS01815 384702..385658 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
HR073_RS01820 385798..387300 + 1503 WP_000205837.1 sugar ABC transporter ATP-binding protein -
HR073_RS01825 387314..388336 + 1023 WP_001367697.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T159059 WP_000239581.1 NZ_CP054227:383433-383783 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T159059 NZ_CP069945:c4586668-4586561 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT159059 WP_001223213.1 NZ_CP054227:383188-383439 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT159059 NZ_CP069945:4586716-4586782 [Escherichia coli]
GGTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References