Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 376495..377030 Replicon plasmid unnamed1
Accession NZ_CP054208
Organism Rhodococcus qingshengii strain CX-1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HRR33_RS32305 Protein ID WP_209448880.1
Coordinates 376495..376794 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HRR33_RS32310 Protein ID WP_209448881.1
Coordinates 376794..377030 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRR33_RS35590 373539..373646 - 108 Protein_366 ArsR family transcriptional regulator -
HRR33_RS32295 373819..374616 - 798 WP_209448878.1 hypothetical protein -
HRR33_RS32300 374616..376466 - 1851 WP_209448879.1 hypothetical protein -
HRR33_RS32305 376495..376794 - 300 WP_209448880.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HRR33_RS32310 376794..377030 - 237 WP_209448881.1 YlcI/YnfO family protein Antitoxin
HRR33_RS32315 377120..377284 + 165 WP_209448882.1 hypothetical protein -
HRR33_RS32320 377462..378088 - 627 WP_257233060.1 TetR/AcrR family transcriptional regulator -
HRR33_RS32325 378198..379172 - 975 WP_209448884.1 DUF2637 domain-containing protein -
HRR33_RS35595 379802..379954 - 153 WP_007733689.1 hypothetical protein -
HRR33_RS32335 380113..380895 - 783 WP_007733691.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..523504 523504


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 10455.09 Da        Isoelectric Point: 4.6942

>T158952 WP_209448880.1 NZ_CP054208:c376794-376495 [Rhodococcus qingshengii]
MRPIHEANLDTVRPVLVLTREMVRPHLGTVTVAPITGEIRGLSTEVSVLAANGLSADAVVSCDHITTIPVSALGNIIGYL
LPAQEESLSIAVRAAFDLE

Download         Length: 300 bp

>T158952 NZ_CP069893:c4230821-4230435 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8791.92 Da        Isoelectric Point: 6.8809

>AT158952 WP_209448881.1 NZ_CP054208:c377030-376794 [Rhodococcus qingshengii]
MSKQIAVRLPDEIVEFLDDEVREHRAASRASLVLRALERERRRQIAARDAEILSAATSEHDLSPLAHHAVNRQPTGLT

Download         Length: 237 bp

>AT158952 NZ_CP069893:c4230445-4230116 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References