Detailed information of TA system TA158951

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA(toxin)
• Location: 2570937..2571547
• Replicon: chromosome
• Accession: NZ_CP054205
• Organism: Pseudomonas rhodesiae strain NL2019

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A2G0WYT7
• Locus tag: HRH33_RS11770
• Protein ID: WP_034096965.1
• Coordinates: 2571296..2571547 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HRH33_RS11765
• Protein ID: WP_167418647.1
• Coordinates: 2570937..2571299 (-)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRH33_RS11745	2566182..2567012	+	831	WP_034137847.1	IclR family transcriptional regulator	-
HRH33_RS11750	2567241..2568092	+	852	WP_167418644.1	hypothetical protein	-
HRH33_RS11755	2568363..2569718	+	1356	WP_167418645.1	MATE family efflux transporter	-
HRH33_RS11760	2569760..2570932	+	1173	WP_167418646.1	MFS transporter	-
HRH33_RS11765	2570937..2571299	-	363	WP_167418647.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HRH33_RS11770	2571296..2571547	-	252	WP_034096965.1	type II toxin-antitoxin system HicA family toxin	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-76)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9497.05 Da
• Isoelectric Point: 10.0458

>T158951 WP_034096965.1 NZ_CP054205:c2571547-2571296 [Pseudomonas rhodesiae]
VSKNEKLLAKLLNEQMAFTWPELVTLLRRLGYTQIEGAGSRVKFDSGDPTAMITLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Nucleotide

• Length: 252 bp

>T158951 NZ_CP069893:3851373-3851675 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13188.05 Da
• Isoelectric Point: 6.9564

>AT158951 WP_167418647.1 NZ_CP054205:c2571299-2570937 [Pseudomonas rhodesiae]
VNNQLKYKGYIGSIEASLEDNCLFGKILFIKALISYEGKTVADLDAAFQAAVDDYLVTCQNLGQTPEKPCKGSFNVRVGH
DLHLAAALAATRKKVTLNDLTRQALNEFLQHHFAELHPSA

Nucleotide

• Length: 363 bp

>AT158951 NZ_CP069893:3851711-3852052 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Structures

Toxin

• AlphaFold DB: A0A2G0WYT7