Detailed information of TA system TA158949

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2268762..2270311
• Replicon: chromosome
• Accession: NZ_CP054198
• Organism: Glaesserella parasuis strain YHP170504

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HQ939_RS11200
• Protein ID: WP_075606267.1
• Coordinates: 2268762..2270078 (-)
• Length: 439 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: U4SAZ6
• Locus tag: HQ939_RS11205
• Protein ID: WP_010786623.1
• Coordinates: 2270072..2270311 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HQ939_RS11180	2264272..2265144	+	873	WP_075606269.1	LysR family transcriptional regulator	-
HQ939_RS11185	2265205..2265819	-	615	WP_075606268.1	disulfide bond formation protein DsbA	-
HQ939_RS11190	2265942..2266832	+	891	WP_021111868.1	LysR family transcriptional regulator	-
HQ939_RS11195	2267378..2268758	+	1381	Protein_2115	PLP-dependent aminotransferase family protein	-
HQ939_RS11200	2268762..2270078	-	1317	WP_075606267.1	type II toxin-antitoxin system HipA family toxin	Toxin
HQ939_RS11205	2270072..2270311	-	240	WP_010786623.1	helix-turn-helix domain-containing protein	Antitoxin
HQ939_RS11210	2270459..2271286	-	828	WP_005713289.1	alpha/beta hydrolase	-
HQ939_RS11215	2271417..2272862	+	1446	WP_021116416.1	metalloprotease TldD	-
HQ939_RS11220	2273090..2274187	+	1098	WP_173631973.1	ISAs1 family transposase	-
HQ939_RS11225	2274331..2274741	+	411	WP_020457617.1	preprotein translocase subunit SecE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-104)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-66)

Sequences

Toxin

Protein

• Length: 439 a.a.
• Molecular weight: 50022.31 Da
• Isoelectric Point: 7.9228

>T158949 WP_075606267.1 NZ_CP054198:c2270078-2268762 [Glaesserella parasuis]
MVMRLRVLMNGEMVGYFDRTLSGSHHFTYAESWLNSPLARPISLSMPLQRATYQGKEVINFFDNLLPDNPQIRARIATRF
NAETQQPFDLLAKIGRDAAGAITLLGEDEQIPNHRIIQATELNESEMAKILQSYQYNVPLGMIDNNQDFRISIAGAQEKT
ALLWHNGKWKLPHGLTPTTHIFKLPMGEIRTPKHLLDLSKSVDNELVCLRLFSAFNIPSANVELLEMNDIRALAVERFDR
RLSQDGSYFLRLPYEDFCQAFGLSPTQKYESDGGIGIGDMMNKLLYSSNSNDRRQFMQTQFLFWLLAAIDGHAKNFSLAI
EKQGRYHLSPVYDVLSAYPMLGGKGWHHSELQMAMSLRSTQKGKKWHWSKIYAEHFYATAKFVGFSSSDMKQVIEQICDT
VQETIDRVATTLPKQIDENVRDQIFTGVIKQVQKVSMK

Nucleotide

• Length: 1317 bp

>T158949 NZ_CP069893:c3508324-3507947 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCTTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CAACTACAGAATGGTGAACGACATCATCCGGGGTGAACATTCGGAGGCGAAACGATGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9059.47 Da
• Isoelectric Point: 9.7684

>AT158949 WP_010786623.1 NZ_CP054198:c2270311-2270072 [Glaesserella parasuis]
MLITTPDMLGNSLRDIRKQKKLSQMQIANQVALRQATISTFEKKTDKATIETLFKLLSGLGYELHIQPRPEKTEGNDEW

Nucleotide

• Length: 240 bp

>AT158949 NZ_CP069893:c3508745-3508371 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCATCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Structures

Antitoxin

• AlphaFold DB: U4SAZ6