Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1460730..1461507 Replicon chromosome
Accession NZ_CP054198
Organism Glaesserella parasuis strain YHP170504

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A836YXW5
Locus tag HQ939_RS07465 Protein ID WP_016527794.1
Coordinates 1461007..1461507 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID U4SPD7
Locus tag HQ939_RS07460 Protein ID WP_005710653.1
Coordinates 1460730..1461017 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQ939_RS07440 1457097..1457597 - 501 WP_021115009.1 CvpA family protein -
HQ939_RS07445 1457702..1459279 - 1578 WP_075606084.1 FAD-binding protein -
HQ939_RS07450 1459454..1460191 - 738 WP_075606085.1 peptidoglycan editing factor PgeF -
HQ939_RS07455 1460195..1460584 - 390 WP_021116694.1 RidA family protein -
HQ939_RS07460 1460730..1461017 + 288 WP_005710653.1 DUF1778 domain-containing protein Antitoxin
HQ939_RS07465 1461007..1461507 + 501 WP_016527794.1 GNAT family N-acetyltransferase Toxin
HQ939_RS07470 1461535..1462536 + 1002 WP_010786647.1 nucleoid-associated protein YejK -
HQ939_RS07475 1462597..1462932 + 336 WP_016527793.1 outer membrane protein assembly factor BamE -
HQ939_RS07480 1463086..1464201 + 1116 WP_043894690.1 anhydro-N-acetylmuramic acid kinase -
HQ939_RS07485 1464213..1465127 + 915 WP_075606086.1 N-acetylmuramic acid 6-phosphate etherase -
HQ939_RS07490 1465169..1465483 + 315 WP_173632064.1 YqcC family protein -
HQ939_RS07495 1465480..1466208 + 729 WP_021111606.1 tRNA pseudouridine(65) synthase TruC -
HQ939_RS07500 1466226..1466381 + 156 WP_021111605.1 YoaH family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(4-87)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 19081.26 Da        Isoelectric Point: 9.2835

>T158948 WP_016527794.1 NZ_CP054198:1461007-1461507 [Glaesserella parasuis]
MKSKFIEEPLTKHHQREAFDCGNLEMNRFFKQYARQSHEKGTSKTYISRHLDSQQIIGFYTITLSALDQQHLPELCKKRF
GYYPIPLFTLARLAVDIRYQKQGIGGMLLVKALKRCAIVAEQVGGIGLLIEAKDEDISRWYQSYGAIPLENMPLTLILLF
DTIKGL

Download         Length: 501 bp

>T158948 NZ_CP069893:2968453-2968626 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10917.47 Da        Isoelectric Point: 6.4650

>AT158948 WP_005710653.1 NZ_CP054198:1460730-1461017 [Glaesserella parasuis]
MPQIANALNDRMSIRISTEDKQTLIRAVALTHTNITEFVLQRILPSAREIIQQYDNRQFSPQDLSLIMELLDNPPKANTK
LQQAAKLAKESYHEE

Download         Length: 288 bp

>AT158948 NZ_CP069893:2968129-2968425 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAGTTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836YXW5

Antitoxin

Source ID Structure
AlphaFold DB U4SPD7

References