Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1232603..1233231 | Replicon | chromosome |
| Accession | NZ_CP054198 | ||
| Organism | Glaesserella parasuis strain YHP170504 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | U4SJQ6 |
| Locus tag | HQ939_RS06255 | Protein ID | WP_005714427.1 |
| Coordinates | 1232603..1232785 (+) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | U4SMI8 |
| Locus tag | HQ939_RS06260 | Protein ID | WP_021110735.1 |
| Coordinates | 1232824..1233231 (+) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HQ939_RS06210 | 1227800..1227994 | - | 195 | WP_021110729.1 | hypothetical protein | - |
| HQ939_RS06215 | 1228194..1229018 | - | 825 | WP_021116916.1 | phage antirepressor N-terminal domain-containing protein | - |
| HQ939_RS06220 | 1229333..1229500 | - | 168 | WP_021110921.1 | hypothetical protein | - |
| HQ939_RS06225 | 1229797..1230015 | + | 219 | WP_021116917.1 | hypothetical protein | - |
| HQ939_RS06230 | 1230068..1230886 | - | 819 | WP_043895698.1 | damage-inducible protein D | - |
| HQ939_RS06235 | 1231251..1231436 | + | 186 | WP_021116919.1 | hypothetical protein | - |
| HQ939_RS06240 | 1231445..1231822 | - | 378 | WP_021116920.1 | hypothetical protein | - |
| HQ939_RS06245 | 1231819..1232223 | - | 405 | WP_021116921.1 | RusA family crossover junction endodeoxyribonuclease | - |
| HQ939_RS06250 | 1232220..1232510 | - | 291 | WP_021110734.1 | DUF1364 domain-containing protein | - |
| HQ939_RS06255 | 1232603..1232785 | + | 183 | WP_005714427.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| HQ939_RS06260 | 1232824..1233231 | + | 408 | WP_021110735.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| HQ939_RS06265 | 1233265..1233693 | - | 429 | WP_021110736.1 | recombination protein NinB | - |
| HQ939_RS06270 | 1233792..1233989 | - | 198 | Protein_1164 | hypothetical protein | - |
| HQ939_RS06275 | 1234012..1234683 | - | 672 | WP_173632054.1 | holin | - |
| HQ939_RS06280 | 1234683..1235468 | - | 786 | WP_021110739.1 | replication protein | - |
| HQ939_RS06285 | 1235465..1236100 | - | 636 | WP_052316815.1 | phage regulatory protein/antirepressor Ant | - |
| HQ939_RS06290 | 1236196..1236471 | - | 276 | WP_021116926.1 | hypothetical protein | - |
| HQ939_RS06295 | 1236492..1236698 | - | 207 | WP_012621794.1 | helix-turn-helix transcriptional regulator | - |
| HQ939_RS06300 | 1236834..1237487 | + | 654 | WP_021110742.1 | LexA family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1197548..1254656 | 57108 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6803.94 Da Isoelectric Point: 10.7158
>T158946 WP_005714427.1 NZ_CP054198:1232603-1232785 [Glaesserella parasuis]
VDSETMIKLLKKNGWELDSIVGSHHHFEKKNQKGAGKVTVPHPRKDLGFLEKKIRKQAGL
VDSETMIKLLKKNGWELDSIVGSHHHFEKKNQKGAGKVTVPHPRKDLGFLEKKIRKQAGL
Download Length: 183 bp
>T158946 NZ_CP069893:2428707-2429084 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCACTACGGCCTCGCGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCGGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCACTACGGCCTCGCGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCGGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 136 a.a. Molecular weight: 14904.94 Da Isoelectric Point: 4.6143
>AT158946 WP_021110735.1 NZ_CP054198:1232824-1233231 [Glaesserella parasuis]
MLYPLIFEQVSDGYVVAIPDIDGCYSAGDTLEETYSNVKQAIALHLESVVKDGGEIPTPTAIENHKNDPDLDGHNVFFGV
VDVDLSHLMGKAEKINITLPSYLIKRIDDFVAVHKEYKNRSNFLAKIAADKILTA
MLYPLIFEQVSDGYVVAIPDIDGCYSAGDTLEETYSNVKQAIALHLESVVKDGGEIPTPTAIENHKNDPDLDGHNVFFGV
VDVDLSHLMGKAEKINITLPSYLIKRIDDFVAVHKEYKNRSNFLAKIAADKILTA
Download Length: 408 bp
>AT158946 NZ_CP069893:2428249-2428617 [Escherichia coli]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|