Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 691270..691805 Replicon chromosome
Accession NZ_CP054198
Organism Glaesserella parasuis strain YHP170504

Toxin (Protein)


Gene name relE Uniprot ID A0A837AG59
Locus tag HQ939_RS03815 Protein ID WP_010785923.1
Coordinates 691521..691805 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A837AF96
Locus tag HQ939_RS03810 Protein ID WP_021118772.1
Coordinates 691270..691524 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQ939_RS03790 686826..687368 + 543 WP_021112096.1 adenine phosphoribosyltransferase -
HQ939_RS03795 687456..689474 + 2019 WP_075606147.1 DNA polymerase III subunit gamma/tau -
HQ939_RS03800 689480..690376 + 897 WP_005712691.1 ABC transporter ATP-binding protein -
HQ939_RS03805 690398..691153 + 756 WP_173631999.1 ABC transporter permease -
HQ939_RS03810 691270..691524 + 255 WP_021118772.1 hypothetical protein Antitoxin
HQ939_RS03815 691521..691805 + 285 WP_010785923.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HQ939_RS03820 692015..693565 + 1551 WP_021112100.1 exodeoxyribonuclease I -
HQ939_RS03825 693648..694607 + 960 WP_021117960.1 S-adenosyl-l-methionine hydroxide adenosyltransferase family protein -
HQ939_RS03830 694642..695238 + 597 WP_173632000.1 DNA glycosylase -
HQ939_RS03835 695239..696060 + 822 WP_042906514.1 PHP domain-containing protein -
HQ939_RS03840 696167..696658 - 492 WP_005712683.1 acetolactate synthase small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11233.25 Da        Isoelectric Point: 10.5362

>T158944 WP_010785923.1 NZ_CP054198:691521-691805 [Glaesserella parasuis]
MSYTIEFIPSAEKEFRKLSLDLRKQFIEKLKERAENPRVESAKLRGMKDCYKIKLRNAGYRLVYQVIDERIVIKVVALGK
RERNDVYQKAQLRL

Download         Length: 285 bp

>T158944 NZ_CP069893:c2202726-2202619 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9347.72 Da        Isoelectric Point: 4.4131

>AT158944 WP_021118772.1 NZ_CP054198:691270-691524 [Glaesserella parasuis]
MPSIILTNTVASITELKTNPMATFNAAGGEAIAILNRNEPAFYCVPPHIYEYLIELADDAELAKLVEERQHEKSYKVDLA
DLLK

Download         Length: 255 bp

>AT158944 NZ_CP069893:2202774-2202840 [Escherichia coli]
GGTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837AG59

Antitoxin

Source ID Structure
AlphaFold DB A0A837AF96

References