Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 613507..614087 Replicon chromosome
Accession NZ_CP054198
Organism Glaesserella parasuis strain YHP170504

Toxin (Protein)


Gene name mazF Uniprot ID A0A143CFE3
Locus tag HQ939_RS03430 Protein ID WP_005710599.1
Coordinates 613507..613851 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID U4SAI4
Locus tag HQ939_RS03435 Protein ID WP_005710601.1
Coordinates 613848..614087 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQ939_RS03420 611429..612820 - 1392 WP_021117914.1 MATE family efflux transporter -
HQ939_RS03425 612833..613501 - 669 WP_021118711.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
HQ939_RS03430 613507..613851 - 345 WP_005710599.1 endoribonuclease MazF Toxin
HQ939_RS03435 613848..614087 - 240 WP_005710601.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HQ939_RS03440 614273..615148 + 876 WP_021113313.1 putative selenate ABC transporter substrate-binding protein -
HQ939_RS03445 615260..616009 + 750 WP_021113386.1 phosphonate ABC transporter ATP-binding protein -
HQ939_RS03450 615999..616784 + 786 WP_075621118.1 ABC transporter permease subunit -
HQ939_RS03455 616781..617629 + 849 WP_035494055.1 ABC transporter permease subunit -
HQ939_RS03460 617691..618383 + 693 WP_021118715.1 tellurite resistance TerB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12830.81 Da        Isoelectric Point: 7.9277

>T158943 WP_005710599.1 NZ_CP054198:c613851-613507 [Glaesserella parasuis]
MTTQEYIPDVGDIIWLDFDPQAGHEQAGHRPALVLTPTIYNRQTGLLICCPLTTKVKGYPFEVNIAGTPQNVVLSDQIKS
LDWRIRHAKFKGKINHHQLSEVKAKIATLLQISE

Download         Length: 345 bp

>T158943 NZ_CP069893:c2202243-2202136 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8782.21 Da        Isoelectric Point: 5.0351

>AT158943 WP_005710601.1 NZ_CP054198:c614087-613848 [Glaesserella parasuis]
MQVAVKKWGNSVGIRIPALLSNSLKLQAESLVDIQEVDGRLIIEPIKPKYNLEQLLSGITEDNLHNEVDFGKPVGKEML

Download         Length: 240 bp

>AT158943 NZ_CP069893:2202300-2202357 [Escherichia coli]
TCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A143CFE3

Antitoxin

Source ID Structure
AlphaFold DB U4SAI4

References