Detailed information of TA system TA158942

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 330859..332546
• Replicon: chromosome
• Accession: NZ_CP054198
• Organism: Glaesserella parasuis strain YHP170504

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: U4SB19
• Locus tag: HQ939_RS02090
• Protein ID: WP_021111224.1
• Coordinates: 330859..332202 (+)
• Length: 448 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HQ939_RS02095
• Protein ID: WP_015940035.1
• Coordinates: 332202..332546 (+)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HQ939_RS02060	326312..326851	-	540	WP_075621178.1	sel1 repeat family protein	-
HQ939_RS02065	326853..327500	-	648	WP_075621179.1	sel1 repeat family protein	-
HQ939_RS02070	327711..327905	+	195	Protein_347	hypothetical protein	-
HQ939_RS02075	328148..329827	+	1680	WP_075621181.1	DNA repair protein RecN	-
HQ939_RS02080	329907..330134	-	228	Protein_349	transposase	-
HQ939_RS02085	330308..330745	+	438	WP_075621182.1	ribosomal protein S18-alanine N-acetyltransferase	-
HQ939_RS02090	330859..332202	+	1344	WP_021111224.1	type II toxin-antitoxin system HipA family toxin	Toxin
HQ939_RS02095	332202..332546	+	345	WP_015940035.1	helix-turn-helix domain-containing protein	Antitoxin
HQ939_RS02100	332575..333900	+	1326	WP_021117781.1	ATP-dependent RNA helicase SrmB	-
HQ939_RS02105	334021..334653	+	633	WP_021110345.1	lipoprotein insertase outer membrane protein LolB	-
HQ939_RS02110	334655..335500	+	846	WP_075606354.1	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase	-
HQ939_RS02115	335528..336478	+	951	WP_005713153.1	ribose-phosphate pyrophosphokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (161-407)

Antitoxin

• Cro/C1-type helix-turn-helix domain (43-92)

Sequences

Toxin

Protein

• Length: 448 a.a.
• Molecular weight: 51106.20 Da
• Isoelectric Point: 5.4867

>T158942 WP_021111224.1 NZ_CP054198:330859-332202 [Glaesserella parasuis]
MQIEPLILQAYIADRWQDIAILTFQADYSLNDFSYLHDLTEILSDNDKAVSFNYPVEFFPHRSVSGWFAFLDDIVPSGAS
RRYWLQKLDIAHLPMAQQNYLLLKQGTIAPVGHLRVKQAVSSFVENEPSRLFEIDDVINRQADFLEYANQRGAMAGGATG
AGGEAPKLLLRQTATRQVWIDNLQQGASSDDFYLVKFPRGKRSVIDCDILRAEFHYYHELASMGFDTIDTTKMRLEEGER
YPSLWLPRFDVYRNEQGKMARYAVESVYAMLEKGAGSLLDHEKVIRQLIAKIETSHLVETGMFFDKQAFVIEWVRRDLLN
IAFGNSDNHGRNTAFLRNQNRIWLAPIYDFAPMKADPEGIPRTTMWDSKGHPALELGGEYRFDLIAEQLDDLCPADKLLD
ALRQTAQQLVGLKARLEARGVPTAILTYPSISLDYLPEKLKRWQLLS

Nucleotide

• Length: 1344 bp

>T158942 NZ_CP069893:c2122385-2122110 [Escherichia coli]
ATGAGAACCCAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAATCTCCTGTTCCTCAAGG
GATTAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTT
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 13225.52 Da
• Isoelectric Point: 10.2782

>AT158942 WP_015940035.1 NZ_CP054198:332202-332546 [Glaesserella parasuis]
MEEIKQARASKSKKTLDIYQRATVRDEIARKLLLNEMSLGQALKYLRLHLLAMKQERYAEIVKVSRKTLSDLENDKGNYS
IDIINQVLRPFELQLGVVPMNKTLLRQVLNEQAV

Nucleotide

• Length: 345 bp

>AT158942 NZ_CP069893:c2122113-2121754 [Escherichia coli]
ATGATCAAACTGAAGACACCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGTATTCAGGGGCTGCAAAAAGAAGGGG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACATTACGCTATCCAGAATCGCTGAGTGAACGCCTTACTAATGCGGCTGCGCAGCAACAAGTCTCTGTAAATACTTA
TATTATTGAAACGCTAAATGAGCGTTTGAATCATTTATAA

Structures

Toxin

• AlphaFold DB: U4SB19