Detailed information of TA system TA158941

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 246129..246768
• Replicon: chromosome
• Accession: NZ_CP054198
• Organism: Glaesserella parasuis strain YHP170504

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A6I4QYS7
• Locus tag: HQ939_RS01670
• Protein ID: WP_021114433.1
• Coordinates: 246433..246768 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HQ939_RS01665
• Protein ID: WP_164681833.1
• Coordinates: 246129..246425 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HQ939_RS01630	241222..242061	+	840	WP_021117455.1	hypothetical protein	-
HQ939_RS01635	242090..242506	+	417	WP_021117454.1	hypothetical protein	-
HQ939_RS01640	242520..242771	+	252	WP_042906724.1	hypothetical protein	-
HQ939_RS01645	242999..243289	+	291	WP_075606729.1	DUF805 domain-containing protein	-
HQ939_RS01650	243292..243705	+	414	WP_075606728.1	hypothetical protein	-
HQ939_RS01655	243840..244966	-	1127	Protein_268	IS3 family transposase	-
HQ939_RS01660	245067..246056	-	990	WP_021110908.1	16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC	-
HQ939_RS01665	246129..246425	-	297	WP_164681833.1	putative addiction module antidote protein	Antitoxin
HQ939_RS01670	246433..246768	-	336	WP_021114433.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HQ939_RS01675	246927..247331	+	405	WP_021110905.1	DNA polymerase III subunit psi	-
HQ939_RS01680	247446..247757	+	312	WP_042906459.1	hypothetical protein	-
HQ939_RS01685	247850..248671	+	822	WP_042906460.1	hypothetical protein	-
HQ939_RS01690	248870..249614	+	745	Protein_275	transposase	-
HQ939_RS01695	249804..249989	-	186	WP_005713975.1	zf-HC2 domain-containing protein	-
HQ939_RS01700	249986..250558	-	573	WP_035522608.1	sigma-70 family RNA polymerase sigma factor	-
HQ939_RS01705	250699..250890	+	192	Protein_278	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	243840..255083	11243

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-96)

Antitoxin

• Uncharacterized protein HI1420 (9-91)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12079.77 Da
• Isoelectric Point: 9.8168

>T158941 WP_021114433.1 NZ_CP054198:c246768-246433 [Glaesserella parasuis]
MSGIINQIVITDNFSKWLDGLKNPIAKATVARRIKNAVKGNFGDHKALAGTGGLYEMRIATGAGYRIYYAQQGDVIYILL
QGGDKSTQQADIEKAKALWAELKQTGGSNEY

Nucleotide

• Length: 336 bp

>T158941 NZ_CP069893:c2094891-2094514 [Escherichia coli]
ATGACCATTCAGTTTATCTCAGCGGAGGAGATAATTTATTTCCACGATAAATTGCTTAGCGTTACACCAGGTGTAACAGG
AATGTCCGATCCAGGGCGAGCAGAAGCGCTTTTGTACCGGGTACTGAATAAGTATGAGTATGAAGGCGTTTCTGATCTTT
GGTTGCTGGCGGCGATGCATCTATTGGCAATCTCGCGCGGTCATATCTTTAATGATGGTAATAAGCGCACCGCACTGTTT
ATCACGCTATTATTCCTTAAACGTAACGGCATCATACTTGCTGCAAACCCAGAGTTTGTAGAATTGACGGTTGATGTGGC
GGCGGGAAAAGTATCGTTAGAAGATATCGTTACCCGCTTGCGTCAACGCGGTACCTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10948.49 Da
• Isoelectric Point: 4.8951

>AT158941 WP_164681833.1 NZ_CP054198:c246425-246129 [Glaesserella parasuis]
MAEKHGLRPFDVAEFLDNEETIQAYLAEVLKEGDQDEFLEALNDVARARGIAELAKQTGLGRESLYKTLSKGSKPRFETI
QKILGAFNLVLIPQIKNS

Nucleotide

• Length: 297 bp

>AT158941 NZ_CP069893:c2095109-2094888 [Escherichia coli]
ATGCATACCATGAACTACAGCGAAGCGCGGCAGAACCTTGCATTAGTTCTGGAAACAGCGGCGACAGGTACTCCGGTAAC
GATCACGAGGCGTGGGCATAAGGCAGCTGTGATTATCAGCGCAGAAGAGTTTGAACGTTACCAGAAGGCTAAACTGGACG
CAGAATTTGACGCCATCATGGCTATTCATGGCAGCGAAATTAAGGAGTTAGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A6I4QYS7