Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3508507..3509125 Replicon chromosome
Accession NZ_CP054191
Organism Escherichia coli strain TH9F11

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HRL54_RS17045 Protein ID WP_001291435.1
Coordinates 3508907..3509125 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HRL54_RS17040 Protein ID WP_000344800.1
Coordinates 3508507..3508881 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRL54_RS17030 (3503596) 3503596..3504789 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HRL54_RS17035 (3504812) 3504812..3507961 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
HRL54_RS17040 (3508507) 3508507..3508881 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HRL54_RS17045 (3508907) 3508907..3509125 + 219 WP_001291435.1 HHA domain-containing protein Toxin
HRL54_RS17050 (3509296) 3509296..3509847 + 552 WP_000102564.1 maltose O-acetyltransferase -
HRL54_RS17055 (3509963) 3509963..3510433 + 471 WP_000136192.1 YlaC family protein -
HRL54_RS17060 (3510597) 3510597..3512147 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HRL54_RS17065 (3512189) 3512189..3512542 - 354 WP_000878141.1 DUF1428 family protein -
HRL54_RS17075 (3512921) 3512921..3513232 + 312 WP_000409911.1 MGMT family protein -
HRL54_RS17080 (3513263) 3513263..3513835 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T158928 WP_001291435.1 NZ_CP054191:3508907-3509125 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T158928 NZ_CP069890:c3989265-3989158 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT158928 WP_000344800.1 NZ_CP054191:3508507-3508881 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT158928 NZ_CP069890:3989318-3989379 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References