Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1875395..1876230 Replicon chromosome
Accession NZ_CP054191
Organism Escherichia coli strain TH9F11

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1U9SHU4
Locus tag HRL54_RS08925 Protein ID WP_000854752.1
Coordinates 1875395..1875772 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag HRL54_RS08930 Protein ID WP_001278232.1
Coordinates 1875862..1876230 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRL54_RS08890 (1870915) 1870915..1871388 + 474 WP_001105384.1 DNA gyrase inhibitor SbmC -
HRL54_RS08895 (1871586) 1871586..1872644 + 1059 WP_001200892.1 FUSC family protein -
HRL54_RS08900 (1872816) 1872816..1873145 + 330 WP_000450409.1 DUF496 family protein -
HRL54_RS08905 (1873246) 1873246..1873611 - 366 WP_223350516.1 EutP/PduV family microcompartment system protein -
HRL54_RS08910 (1873882) 1873882..1874253 - 372 WP_001295631.1 IS110 family transposase -
HRL54_RS08915 (1875069) 1875069..1875149 - 81 Protein_1742 hypothetical protein -
HRL54_RS08920 (1875249) 1875249..1875398 - 150 Protein_1743 DUF5983 family protein -
HRL54_RS08925 (1875395) 1875395..1875772 - 378 WP_000854752.1 TA system toxin CbtA family protein Toxin
HRL54_RS08930 (1875862) 1875862..1876230 - 369 WP_001278232.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
HRL54_RS08935 (1876393) 1876393..1876614 - 222 WP_000692345.1 DUF987 domain-containing protein -
HRL54_RS08940 (1876677) 1876677..1877153 - 477 WP_001186725.1 RadC family protein -
HRL54_RS08945 (1877169) 1877169..1877654 - 486 WP_021533007.1 antirestriction protein -
HRL54_RS08950 (1877709) 1877709..1878527 - 819 WP_001234620.1 DUF932 domain-containing protein -
HRL54_RS08955 (1878627) 1878627..1878860 - 234 WP_001119729.1 DUF905 family protein -
HRL54_RS08960 (1878939) 1878939..1879394 - 456 WP_000581504.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14076.08 Da        Isoelectric Point: 8.2905

>T158917 WP_000854752.1 NZ_CP054191:c1875772-1875395 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T158917 NZ_CP069890:c1557675-1557568 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCACGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT158917 WP_001278232.1 NZ_CP054191:c1876230-1875862 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT158917 NZ_CP069890:1557723-1557789 [Escherichia coli]
GGTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9SHU4

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References