Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1355330..1355955 Replicon chromosome
Accession NZ_CP054191
Organism Escherichia coli strain TH9F11

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HRL54_RS06590 Protein ID WP_000911330.1
Coordinates 1355557..1355955 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag HRL54_RS06585 Protein ID WP_000450524.1
Coordinates 1355330..1355557 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRL54_RS06560 (1351133) 1351133..1351603 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
HRL54_RS06565 (1351603) 1351603..1352175 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
HRL54_RS06570 (1352321) 1352321..1353199 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
HRL54_RS06575 (1353216) 1353216..1354250 + 1035 WP_001330579.1 outer membrane protein assembly factor BamC -
HRL54_RS06580 (1354463) 1354463..1355176 + 714 WP_001347624.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
HRL54_RS06585 (1355330) 1355330..1355557 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
HRL54_RS06590 (1355557) 1355557..1355955 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
HRL54_RS06595 (1356102) 1356102..1356965 + 864 WP_001267498.1 neutral zinc metallopeptidase -
HRL54_RS06600 (1356980) 1356980..1358995 + 2016 WP_000829292.1 tRNA cytosine(34) acetyltransferase TmcA -
HRL54_RS06605 (1359069) 1359069..1359767 + 699 WP_000679812.1 esterase -
HRL54_RS06610 (1359848) 1359848..1360048 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T158915 WP_000911330.1 NZ_CP054191:1355557-1355955 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T158915 NZ_CP069890:c849368-848961 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT158915 WP_000450524.1 NZ_CP054191:1355330-1355557 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT158915 NZ_CP069890:c849615-849349 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References