Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 764393..765191 Replicon chromosome
Accession NZ_CP054191
Organism Escherichia coli strain TH9F11

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag HRL54_RS03700 Protein ID WP_000854735.1
Coordinates 764393..764770 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1EW42
Locus tag HRL54_RS03705 Protein ID WP_032153712.1
Coordinates 764817..765191 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRL54_RS03670 (760361) 760361..761623 - 1263 WP_001218875.1 integrase arm-type DNA-binding domain-containing protein -
HRL54_RS03675 (762087) 762087..762413 - 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
HRL54_RS03680 (762410) 762410..762673 - 264 WP_025492088.1 type II toxin-antitoxin system ParD family antitoxin -
HRL54_RS03685 (762745) 762745..763611 - 867 WP_032153714.1 DUF4942 domain-containing protein -
HRL54_RS03690 (763696) 763696..763893 - 198 WP_000839265.1 DUF957 domain-containing protein -
HRL54_RS03695 (763905) 763905..764396 - 492 WP_023155722.1 DUF5983 family protein -
HRL54_RS03700 (764393) 764393..764770 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
HRL54_RS03705 (764817) 764817..765191 - 375 WP_032153712.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
HRL54_RS03710 (765271) 765271..765492 - 222 WP_000692345.1 DUF987 domain-containing protein -
HRL54_RS03715 (765561) 765561..766037 - 477 WP_001186715.1 RadC family protein -
HRL54_RS03720 (766053) 766053..766538 - 486 WP_032153711.1 antirestriction protein -
HRL54_RS03725 (766630) 766630..767448 - 819 WP_001234693.1 DUF932 domain-containing protein -
HRL54_RS03730 (767539) 767539..767748 - 210 WP_023155727.1 DUF905 family protein -
HRL54_RS03735 (767778) 767778..768455 - 678 WP_023155728.1 hypothetical protein -
HRL54_RS03740 (768574) 768574..769458 - 885 WP_024166630.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR papI / papB 762087..829568 67481


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T158912 WP_000854735.1 NZ_CP054191:c764770-764393 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T158912 NZ_CP069883:c130566-130150 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13697.51 Da        Isoelectric Point: 6.6240

>AT158912 WP_032153712.1 NZ_CP054191:c765191-764817 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT158912 NZ_CP069883:c130793-130563 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1EW42

References