Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4808113..4808948 Replicon chromosome
Accession NZ_CP054169
Organism Escherichia coli strain STO_Bone1B

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3P5DZK2
Locus tag HRS04_RS24070 Protein ID WP_060578072.1
Coordinates 4808113..4808490 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3P5E0D5
Locus tag HRS04_RS24075 Protein ID WP_060578073.1
Coordinates 4808580..4808948 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRS04_RS24050 (4804205) 4804205..4805743 - 1539 WP_001187177.1 lysine decarboxylation/transport transcriptional activator CadC -
HRS04_RS24055 (4806492) 4806492..4807334 - 843 WP_060578071.1 DUF4942 domain-containing protein -
HRS04_RS24060 (4807419) 4807419..4807616 - 198 WP_000839256.1 DUF957 domain-containing protein -
HRS04_RS24065 (4807628) 4807628..4808116 - 489 WP_000761718.1 DUF5983 family protein -
HRS04_RS24070 (4808113) 4808113..4808490 - 378 WP_060578072.1 TA system toxin CbtA family protein Toxin
HRS04_RS24075 (4808580) 4808580..4808948 - 369 WP_060578073.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HRS04_RS24080 (4808959) 4808959..4809654 - 696 WP_060578074.1 hypothetical protein -
HRS04_RS24085 (4809673) 4809673..4809894 - 222 WP_000692323.1 DUF987 domain-containing protein -
HRS04_RS24090 (4809963) 4809963..4810439 - 477 WP_069067380.1 RadC family protein -
HRS04_RS24095 (4810455) 4810455..4810940 - 486 WP_000214415.1 antirestriction protein -
HRS04_RS24100 (4811032) 4811032..4811244 - 213 Protein_4498 DUF945 domain-containing protein -
HRS04_RS24105 (4811416) 4811416..4812957 + 1542 WP_199206482.1 IS21-like element ISEc12 family transposase -
HRS04_RS24110 (4812972) 4812972..4813718 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14208.17 Da        Isoelectric Point: 7.2920

>T158884 WP_060578072.1 NZ_CP054169:c4808490-4808113 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRMVNNITQGKHPEAQQ

Download         Length: 378 bp

>T158884 NZ_CP069873:c4486896-4486579 [Klebsiella pneumoniae]
ATGTTGACTTTTATTGAACTACAAGGTTTCAGTAAGCGACGCCAGGTGCTGTTGCAGGATGATGAATTTCGGGCCTTTCA
GGAAATCCTTATAAACGATCCCGAGGCTGGGGACACAATTTCGGGAACCGGTGGTTTTCGTAAAATTCGCTGGAGTCGTC
CCGGGATGGGGAAGCGCGGCGGTGTACGAGTGATTTACTATAATGTAACGAAAAAGGGAAGAATTTACCTGGCGCTCATC
TATCCTAAAAATGAACAGGATGAGTTAAATCAGGAGCAAAAAAAGATGTTGAGACAAGTGGCTGATTTAATAAACTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13810.52 Da        Isoelectric Point: 6.3177

>AT158884 WP_060578073.1 NZ_CP054169:c4808948-4808580 [Escherichia coli]
VSDSRHETNYPDDHNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT158884 NZ_CP069873:c4486503-4486207 [Klebsiella pneumoniae]
ATGAAAGACGAATTGTTTGCCGATCTGCTGGCGAGTGCAGAAGAAATGGTCAGGATCGAGAAAGGTGAACAAATGCTGAT
GGAGCAGCACGTTCATACCTTCAGCGAAATTGACGTGAAAGCGATACGTGAAGCCACAGGTTTAAAACAGCAGGACTTTG
CAGCGGCCGTTGGCGTTAGCTACGAGTTGGTTAAAAGCTGGGAAACGAAACGACGTCACCCAACCGGTGCAGCCAGAAAG
CTGCTTTTATTGCTTCAGGGTAATCCATTGATTATCAACTTGTTGAAGGTTGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3P5DZK2

Antitoxin

Source ID Structure
AlphaFold DB A0A3P5E0D5

References