Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 702729..703530 Replicon chromosome
Accession NZ_CP054169
Organism Escherichia coli strain STO_Bone1B

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HRS04_RS04350 Protein ID WP_061091468.1
Coordinates 703153..703530 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HRS04_RS04345 Protein ID WP_032215284.1
Coordinates 702729..703106 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRS04_RS04310 (698398) 698398..698940 + 543 WP_033811096.1 hypothetical protein -
HRS04_RS04315 (699301) 699301..699783 + 483 WP_077777324.1 hypothetical protein -
HRS04_RS04320 (700151) 700151..700972 + 822 WP_061091467.1 DUF932 domain-containing protein -
HRS04_RS04325 (700972) 700972..701217 + 246 WP_000680586.1 hypothetical protein -
HRS04_RS04330 (701311) 701311..701784 + 474 WP_000855069.1 antirestriction protein -
HRS04_RS04335 (701800) 701800..702276 + 477 WP_001186774.1 RadC family protein -
HRS04_RS04340 (702345) 702345..702566 + 222 WP_000692307.1 DUF987 domain-containing protein -
HRS04_RS04345 (702729) 702729..703106 + 378 WP_032215284.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HRS04_RS04350 (703153) 703153..703530 + 378 WP_061091468.1 TA system toxin CbtA family protein Toxin
HRS04_RS04355 (703527) 703527..703955 + 429 Protein_651 DUF5983 family protein -
HRS04_RS04360 (703929) 703929..704846 - 918 WP_000520337.1 IS5-like element ISEc35 family transposase -
HRS04_RS04365 (704926) 704926..705075 + 150 Protein_653 DUF5983 family protein -
HRS04_RS04370 (705095) 705095..705292 + 198 WP_128300335.1 DUF957 domain-containing protein -
HRS04_RS04375 (705389) 705389..705949 + 561 Protein_655 DUF4942 domain-containing protein -
HRS04_RS04380 (706021) 706021..707025 + 1005 WP_001179707.1 IS110-like element ISSfl8 family transposase -
HRS04_RS04385 (707307) 707307..707594 + 288 Protein_657 DUF4942 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14223.17 Da        Isoelectric Point: 6.7029

>T158856 WP_061091468.1 NZ_CP054169:703153-703530 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTLFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR

Download         Length: 378 bp

>T158856 NZ_CP069865:c1940294-1940187 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13806.71 Da        Isoelectric Point: 6.7387

>AT158856 WP_032215284.1 NZ_CP054169:702729-703106 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Download         Length: 378 bp

>AT158856 NZ_CP069865:1940342-1940408 [Escherichia coli]
GGTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References