Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4085417..4086261 Replicon chromosome
Accession NZ_CP054161
Organism Escherichia coli strain STO_Bone2

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag HRS05_RS19875 Protein ID WP_000854686.1
Coordinates 4085417..4085800 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag HRS05_RS19880 Protein ID WP_001285602.1
Coordinates 4085881..4086261 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRS05_RS19835 (4080420) 4080420..4080911 - 492 WP_001308552.1 DUF1097 domain-containing protein -
HRS05_RS19840 (4081013) 4081013..4081567 - 555 WP_001001921.1 molecular chaperone YcdY -
HRS05_RS19845 (4081591) 4081591..4082328 - 738 WP_000283664.1 zinc-binding phosphatase -
HRS05_RS19850 (4082383) 4082383..4083321 - 939 WP_001522839.1 glyoxylate/hydroxypyruvate reductase GhrA -
HRS05_RS19860 (4083792) 4083792..4084633 - 842 Protein_3874 DUF4942 domain-containing protein -
HRS05_RS19865 (4084718) 4084718..4084915 - 198 WP_000839253.1 DUF957 domain-containing protein -
HRS05_RS19870 (4084932) 4084932..4085420 - 489 WP_032180032.1 DUF5983 family protein -
HRS05_RS19875 (4085417) 4085417..4085800 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
HRS05_RS19880 (4085881) 4085881..4086261 - 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HRS05_RS19885 (4086272) 4086272..4086955 - 684 WP_000086768.1 hypothetical protein -
HRS05_RS19890 (4086974) 4086974..4087195 - 222 WP_000692298.1 DUF987 domain-containing protein -
HRS05_RS19895 (4087258) 4087258..4087734 - 477 WP_001186726.1 RadC family protein -
HRS05_RS19900 (4087750) 4087750..4088235 - 486 WP_000214307.1 antirestriction protein -
HRS05_RS19905 (4088327) 4088327..4089148 - 822 WP_001761104.1 DUF932 domain-containing protein -
HRS05_RS19910 (4089249) 4089249..4089457 - 209 Protein_3884 DUF905 domain-containing protein -
HRS05_RS19915 (4089558) 4089558..4090013 - 456 WP_235163807.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T158834 WP_000854686.1 NZ_CP054161:c4085800-4085417 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T158834 NZ_CP069861:c796760-796413 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT158834 WP_001285602.1 NZ_CP054161:c4086261-4085881 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT158834 NZ_CP069861:c796413-796114 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References