Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 3417773..3418299 | Replicon | chromosome |
| Accession | NZ_CP054161 | ||
| Organism | Escherichia coli strain STO_Bone2 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | HRS05_RS16375 | Protein ID | WP_000323025.1 |
| Coordinates | 3418012..3418299 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | HRS05_RS16370 | Protein ID | WP_000534858.1 |
| Coordinates | 3417773..3418012 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HRS05_RS16340 (3413035) | 3413035..3413649 | + | 615 | WP_001265627.1 | hypothetical protein | - |
| HRS05_RS16345 (3413652) | 3413652..3414674 | + | 1023 | WP_000915483.1 | DUF4868 domain-containing protein | - |
| HRS05_RS16350 (3415179) | 3415179..3416201 | + | 1023 | Protein_3183 | ISNCY family transposase | - |
| HRS05_RS16355 (3416322) | 3416322..3416471 | + | 150 | WP_011443592.1 | protein YdfW | - |
| HRS05_RS16360 (3416908) | 3416908..3417240 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| HRS05_RS16365 (3417443) | 3417443..3417748 | - | 306 | WP_001326990.1 | protein YdfV | - |
| HRS05_RS16370 (3417773) | 3417773..3418012 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| HRS05_RS16375 (3418012) | 3418012..3418299 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| HRS05_RS16380 (3418371) | 3418371..3418526 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| HRS05_RS16385 (3418743) | 3418743..3418994 | + | 252 | WP_000980994.1 | protein Rem | - |
| HRS05_RS16390 (3419061) | 3419061..3419339 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| HRS05_RS16395 (3419341) | 3419341..3420390 | + | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| HRS05_RS16400 (3420404) | 3420404..3421156 | + | 753 | WP_001047135.1 | antitermination protein | - |
| HRS05_RS16405 (3421434) | 3421434..3421523 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| HRS05_RS16410 (3421578) | 3421578..3421790 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| HRS05_RS16415 (3422091) | 3422091..3422306 | + | 216 | Protein_3196 | cold shock-like protein CspB | - |
| HRS05_RS16420 (3422670) | 3422670..3422840 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| HRS05_RS16425 (3423060) | 3423060..3423275 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3398223..3467228 | 69005 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T158830 WP_000323025.1 NZ_CP054161:3418012-3418299 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T158830 NZ_CP069854:c36496-36014 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT158830 WP_000534858.1 NZ_CP054161:3417773-3418012 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT158830 NZ_CP069854:c36750-36484 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|