Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1873362..1874016 Replicon chromosome
Accession NZ_CP054161
Organism Escherichia coli strain STO_Bone2

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag HRS05_RS08910 Protein ID WP_000244781.1
Coordinates 1873609..1874016 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HRS05_RS08905 Protein ID WP_000354046.1
Coordinates 1873362..1873628 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRS05_RS08885 (1869450) 1869450..1870883 - 1434 WP_001394742.1 6-phospho-beta-glucosidase BglA -
HRS05_RS08890 (1870928) 1870928..1871239 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
HRS05_RS08895 (1871403) 1871403..1872062 + 660 WP_000250274.1 hemolysin III family protein -
HRS05_RS08900 (1872139) 1872139..1873119 - 981 WP_000886087.1 tRNA-modifying protein YgfZ -
HRS05_RS08905 (1873362) 1873362..1873628 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HRS05_RS08910 (1873609) 1873609..1874016 + 408 WP_000244781.1 protein YgfX Toxin
HRS05_RS08915 (1874056) 1874056..1874577 - 522 WP_001055874.1 flavodoxin FldB -
HRS05_RS08920 (1874689) 1874689..1875585 + 897 WP_000806650.1 site-specific tyrosine recombinase XerD -
HRS05_RS08925 (1875610) 1875610..1876320 + 711 WP_000715222.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HRS05_RS08930 (1876326) 1876326..1878059 + 1734 WP_000813233.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T158818 WP_000244781.1 NZ_CP054161:1873609-1874016 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T158818 NZ_CP069852:c3148-2861 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT158818 WP_000354046.1 NZ_CP054161:1873362-1873628 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT158818 NZ_CP069852:c2874-2560 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References