Detailed information of TA system TA158809

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4664222..4664891
• Replicon: chromosome
• Accession: NZ_CP054160
• Organism: Serratia fonticola strain HH13

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: G9399_RS21310
• Protein ID: WP_173408787.1
• Coordinates: 4664222..4664644 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: U2M6Q5
• Locus tag: G9399_RS21315
• Protein ID: WP_021179805.1
• Coordinates: 4664625..4664891 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9399_RS21290 (G9399_05125)	4660066..4660584	+	519	WP_021179810.1	flavodoxin FldB	-
G9399_RS21295 (G9399_05120)	4660620..4662008	-	1389	WP_173408789.1	cell envelope integrity protein CreD	-
G9399_RS21300 (G9399_05115)	4662112..4663530	-	1419	WP_173408788.1	two-component system sensor histidine kinase CreC	-
G9399_RS21305 (G9399_05110)	4663527..4664222	-	696	WP_098929868.1	two-component system response regulator CreB	-
G9399_RS21310 (G9399_05105)	4664222..4664644	-	423	WP_173408787.1	protein YgfX	Toxin
G9399_RS21315 (G9399_05100)	4664625..4664891	-	267	WP_021179805.1	FAD assembly factor SdhE	Antitoxin
G9399_RS21320 (G9399_05095)	4665192..4666184	+	993	WP_173410113.1	tRNA-modifying protein YgfZ	-
G9399_RS21325 (G9399_05090)	4666224..4666721	-	498	WP_021179803.1	DUF2165 domain-containing protein	-
G9399_RS21330 (G9399_05085)	4666953..4667627	-	675	WP_065684483.1	hemolysin III family protein	-
G9399_RS21335 (G9399_05080)	4667864..4668472	+	609	WP_173408786.1	HD domain-containing protein	-
G9399_RS21340 (G9399_05075)	4668812..4669558	-	747	WP_173408785.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-78)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16495.44 Da
• Isoelectric Point: 10.3439

>T158809 WP_173408787.1 NZ_CP054160:c4664644-4664222 [Serratia fonticola]
VAQWRCDVRVSWRTQLVSLLTHGLLILLILIAPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLAERRIEWHGQ
EWLMVNKPWMPGFGILLSLQLIDGKKRHRLWLASDSMSKADWRQLRQRLLFEQSATDEDV

Nucleotide

• Length: 423 bp

>T158809 NZ_CP069847:c2737654-2737121 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10363.93 Da
• Isoelectric Point: 5.5847

>AT158809 WP_021179805.1 NZ_CP054160:c4664891-4664625 [Serratia fonticola]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDADKAVFIRLLECDDPDLFNWLMNHGAPQDQDLQRMVSLIQMRN
KARGPVAM

Nucleotide

• Length: 267 bp

>AT158809 NZ_CP069847:c2737931-2737665 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Antitoxin

• AlphaFold DB: U2M6Q5