Detailed information of TA system TA158807

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3531307..3531936
• Replicon: chromosome
• Accession: NZ_CP054160
• Organism: Serratia fonticola strain HH13

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: G9399_RS16175
• Protein ID: WP_173409082.1
• Coordinates: 3531307..3531495 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A1C7WBI8
• Locus tag: G9399_RS16180
• Protein ID: WP_065684215.1
• Coordinates: 3531523..3531936 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9399_RS16165 (G9399_10325)	3529334..3529963	-	630	WP_161713596.1	TetR/AcrR family transcriptional regulator	-
G9399_RS16170 (G9399_10320)	3530172..3531107	+	936	WP_098930702.1	nitronate monooxygenase	-
G9399_RS16175 (G9399_10315)	3531307..3531495	+	189	WP_173409082.1	type II toxin-antitoxin system HicA family toxin	Toxin
G9399_RS16180 (G9399_10310)	3531523..3531936	+	414	WP_065684215.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
G9399_RS16185 (G9399_10305)	3531969..3532721	-	753	WP_021805696.1	L-cystine ABC transporter ATP-binding protein TcyN	-
G9399_RS16190 (G9399_10300)	3532725..3533387	-	663	WP_021180972.1	cystine ABC transporter permease	-
G9399_RS16195 (G9399_10295)	3533387..3534187	-	801	WP_024528878.1	cystine ABC transporter substrate-binding protein	-
G9399_RS16200 (G9399_10290)	3534306..3535292	-	987	WP_173409081.1	D-cysteine desulfhydrase	-
G9399_RS16205 (G9399_10285)	3535419..3535928	-	510	WP_065684264.1	flagella biosynthesis regulatory protein FliZ	-
G9399_RS16210 (G9399_10280)	3535989..3536711	-	723	WP_173409080.1	RNA polymerase sigma factor FliA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 6959.05 Da
• Isoelectric Point: 10.9062

>T158807 WP_173409082.1 NZ_CP054160:3531307-3531495 [Serratia fonticola]
VKSSELNKRLESHGGVLQRIKGSHHQFKHPNSPLVITVPHPNKDVKLETLRQIMKDAGLLNS

Nucleotide

• Length: 189 bp

>T158807 NZ_CP069847:c1989949-1989632 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15017.74 Da
• Isoelectric Point: 4.8403

>AT158807 WP_065684215.1 NZ_CP054160:3531523-3531936 [Serratia fonticola]
MFYPAYIHAEPDGSASGFFPDVPGCYFAGDSLDQTFQDAKSALDAHFELLSEENQAIPRPQAVSFHLAQGNDALNGGQWL
LVDINMDKFDGRAERINITLPHRLLNRIDSLVQQHPGYGSRSAFLAAAARNELLKAG

Nucleotide

• Length: 414 bp

>AT158807 NZ_CP069847:c1989639-1989352 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACAGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Structures

Antitoxin

• AlphaFold DB: A0A1C7WBI8