Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 3413431..3414065 Replicon chromosome
Accession NZ_CP054160
Organism Serratia fonticola strain HH13

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag G9399_RS15590 Protein ID WP_076940373.1
Coordinates 3413889..3414065 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag G9399_RS15585 Protein ID WP_141132085.1
Coordinates 3413431..3413838 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9399_RS15550 (G9399_10935) 3409030..3409815 - 786 WP_173409124.1 hypothetical protein -
G9399_RS15555 (G9399_10930) 3409965..3410180 - 216 WP_173409123.1 hypothetical protein -
G9399_RS15560 (G9399_10925) 3410858..3411241 - 384 WP_173409122.1 DUF2570 family protein -
G9399_RS15565 (G9399_10920) 3411238..3411861 - 624 WP_173409121.1 glycoside hydrolase family 19 protein -
G9399_RS15570 (G9399_10915) 3411866..3412270 - 405 WP_173409120.1 phage holin family protein -
G9399_RS15575 (G9399_10910) 3412678..3413172 + 495 WP_173409119.1 DUF2441 domain-containing protein -
G9399_RS15580 (G9399_10905) 3413169..3413369 - 201 WP_173409118.1 hypothetical protein -
G9399_RS15585 (G9399_10900) 3413431..3413838 - 408 WP_141132085.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
G9399_RS15590 (G9399_10895) 3413889..3414065 - 177 WP_076940373.1 type II toxin-antitoxin system HicA family toxin Toxin
G9399_RS15595 (G9399_10890) 3414147..3414260 - 114 Protein_3053 protein mom -
G9399_RS15600 (G9399_10885) 3414913..3415470 - 558 WP_186530818.1 DUF1133 family protein -
G9399_RS15605 (G9399_10880) 3415467..3415754 - 288 WP_173409117.1 DUF1364 domain-containing protein -
G9399_RS15610 (G9399_10875) 3415751..3416212 - 462 WP_173409116.1 YbcN family protein -
G9399_RS15615 (G9399_10870) 3416365..3416541 - 177 WP_173409115.1 hypothetical protein -
G9399_RS15620 (G9399_10865) 3416745..3417122 - 378 WP_173409114.1 hypothetical protein -
G9399_RS15625 (G9399_10860) 3417109..3417600 - 492 WP_173409113.1 class I SAM-dependent methyltransferase -
G9399_RS15630 (G9399_10855) 3417597..3418823 - 1227 WP_221035180.1 DNA cytosine methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3368464..3440419 71955


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(79-131)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6665.82 Da        Isoelectric Point: 11.1683

>T158798 WP_076940373.1 NZ_CP054160:c3414065-3413889 [Serratia fonticola]
VKQREFQRWLAAQGAEFSNGSNHLKIYLNGKQTIMPRHPGKEIPEPLRKAILKQLGLK

Download         Length: 177 bp

>T158798 NZ_CP069843:707250-707501 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14801.91 Da        Isoelectric Point: 4.5348

>AT158798 WP_141132085.1 NZ_CP054160:c3413838-3413431 [Serratia fonticola]
MRYPVKFEHDETGWCVSFPDIPEALTGGDTREEALSLAQDALVTAFDFYFEDRRPVPMPSADGEEFVDVPASVAAKVLLL
NAMIATGTTPAELARRMGTRPQEVNRIVTLNHATKIDTIEAALKALGKRLEITAL

Download         Length: 408 bp

>AT158798 NZ_CP069843:707504-707905 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References