Detailed information of TA system TA158797

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeV-yfjZ/CbtA-CbeA
• Location: 1506362..1507141
• Replicon: chromosome
• Accession: NZ_CP054160
• Organism: Serratia fonticola strain HH13

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: G9399_RS06725
• Protein ID: WP_173409683.1
• Coordinates: 1506362..1506694 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: G9399_RS06730
• Protein ID: WP_259526319.1
• Coordinates: 1506773..1507141 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9399_RS06695 (G9399_19890)	1501373..1501591	-	219	WP_173409689.1	AlpA family transcriptional regulator	-
G9399_RS06700 (G9399_19885)	1501714..1502361	-	648	WP_173409688.1	inovirus Gp2 family protein	-
G9399_RS06705 (G9399_19880)	1503002..1503946	+	945	WP_173409687.1	hypothetical protein	-
G9399_RS06710 (G9399_19875)	1504170..1504988	+	819	WP_173409686.1	DUF932 domain-containing protein	-
G9399_RS06715 (G9399_19870)	1505386..1505817	+	432	WP_173409685.1	antirestriction protein	-
G9399_RS06720 (G9399_19865)	1505833..1506321	+	489	WP_173409684.1	DNA repair protein RadC	-
G9399_RS06725 (G9399_19860)	1506362..1506694	+	333	WP_173409683.1	TA system toxin CbtA family protein	Toxin
G9399_RS06730 (G9399_19855)	1506773..1507141	+	369	WP_259526319.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
G9399_RS06735 (G9399_19850)	1507219..1507416	+	198	WP_173409682.1	hypothetical protein	-
G9399_RS06740 (G9399_19845)	1507672..1508574	+	903	WP_173409681.1	sce7726 family protein	-
G9399_RS06745 (G9399_19840)	1508581..1509513	+	933	WP_173409680.1	sce7725 family protein	-
G9399_RS06750 (G9399_19835)	1509516..1510541	+	1026	WP_173409679.1	RES domain-containing protein	-
G9399_RS06755 (G9399_19830)	1510737..1511042	+	306	WP_173409678.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1487399..1515764	28365

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (11-102)

Antitoxin

• Antitoxin CbeA (17-115)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12563.49 Da
• Isoelectric Point: 7.1652

>T158797 WP_173409683.1 NZ_CP054160:1506362-1506694 [Serratia fonticola]
MKTINTTIRIISSPSAFTEYRQLLAWLLKHCYGLELNDTPYHDEQAISQQIENGVTVRETINELVDKFDLVRVDRPGFSL
LAQDPMLNGVDLLRARSALGLRIPVNRRLV

Nucleotide

• Length: 333 bp

>T158797 NZ_CP069842:2913-3200 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGATATACTAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13713.43 Da
• Isoelectric Point: 4.8181

>AT158797 WP_259526319.1 NZ_CP054160:1506773-1507141 [Serratia fonticola]
MREPAPNTDNTNDEMPIWGLQRAITPRLGARLVQQGNRLYFLADRAGFIGTFDPDTLQMLDTAFPVLIEQLESRLRSGEL
DQRRQRCVTVQHAGFICEADTLGSFGHVYIAVYQTTQTPSGE

Nucleotide

• Length: 369 bp

>AT158797 NZ_CP069842:3187-3501 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA