Detailed information of TA system TA158796

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1403612..1404234
• Replicon: chromosome
• Accession: NZ_CP054160
• Organism: Serratia fonticola strain HH13

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: U2M374
• Locus tag: G9399_RS06235
• Protein ID: WP_021180142.1
• Coordinates: 1403612..1403815 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: U2NAN4
• Locus tag: G9399_RS06240
• Protein ID: WP_021180141.1
• Coordinates: 1403866..1404234 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9399_RS06210 (G9399_20365)	1399442..1399930	+	489	WP_173409718.1	YbaY family lipoprotein	-
G9399_RS06215 (G9399_20360)	1399984..1400298	-	315	WP_065686270.1	MGMT family protein	-
G9399_RS06225 (G9399_20350)	1400679..1402466	-	1788	WP_173409717.1	adenine deaminase C-terminal domain-containing protein	-
G9399_RS06230 (G9399_20345)	1402603..1403529	+	927	WP_024484393.1	LysR family transcriptional regulator	-
G9399_RS06235 (G9399_20340)	1403612..1403815	-	204	WP_021180142.1	HHA domain-containing protein	Toxin
G9399_RS06240 (G9399_20335)	1403866..1404234	-	369	WP_021180141.1	Hha toxicity modulator TomB	Antitoxin
G9399_RS06245 (G9399_20330)	1404392..1404745	-	354	WP_065686474.1	hypothetical protein	-
G9399_RS06250 (G9399_20325)	1405125..1405817	+	693	WP_161713396.1	ABC transporter ATP-binding protein	-
G9399_RS06255 (G9399_20320)	1405817..1406674	+	858	WP_065686281.1	metal ABC transporter permease	-
G9399_RS06260 (G9399_20315)	1406700..1407578	+	879	WP_173409716.1	zinc ABC transporter substrate-binding protein	-
G9399_RS06265 (G9399_20310)	1407686..1407826	-	141	WP_021805462.1	type B 50S ribosomal protein L36	-
G9399_RS06270 (G9399_20305)	1407839..1408096	-	258	WP_065686283.1	type B 50S ribosomal protein L31	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-118)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8099.48 Da
• Isoelectric Point: 6.9770

>T158796 WP_021180142.1 NZ_CP054160:c1403815-1403612 [Serratia fonticola]
MTKIDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Nucleotide

• Length: 204 bp

>T158796 NZ_CP069841:72957-73316 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14097.78 Da
• Isoelectric Point: 4.5140

>AT158796 WP_021180141.1 NZ_CP054160:c1404234-1403866 [Serratia fonticola]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNELIEHIASFVMSFKIKYMDEGDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARTFRLFSGEGVCTTMKT

Nucleotide

• Length: 369 bp

>AT158796 NZ_CP069841:73316-73615 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAAACTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Structures

Toxin

• AlphaFold DB: U2M374

Antitoxin

• AlphaFold DB: U2NAN4