Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1403612..1404234 Replicon chromosome
Accession NZ_CP054160
Organism Serratia fonticola strain HH13

Toxin (Protein)


Gene name Hha Uniprot ID U2M374
Locus tag G9399_RS06235 Protein ID WP_021180142.1
Coordinates 1403612..1403815 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID U2NAN4
Locus tag G9399_RS06240 Protein ID WP_021180141.1
Coordinates 1403866..1404234 (-) Length 123 a.a.

Genomic Context

G9399_RS06210G9399_RS06230G9399_RS06250G9399_RS06255G9399_RS06260G9399_RS06215G9399_RS06225G9399_RS06235G9399_RS06240G9399_RS06245G9399_RS06265G9399_RS06270
Location: 1399442..1399930 (489 bp)
Type: Others
Protein ID: WP_173409718.1
Location: 1402603..1403529 (927 bp)
Type: Others
Protein ID: WP_024484393.1
Location: 1405125..1405817 (693 bp)
Type: Others
Protein ID: WP_161713396.1
Location: 1405817..1406674 (858 bp)
Type: Others
Protein ID: WP_065686281.1
Location: 1406700..1407578 (879 bp)
Type: Others
Protein ID: WP_173409716.1
Location: 1399984..1400298 (315 bp)
Type: Others
Protein ID: WP_065686270.1
Location: 1400679..1402466 (1788 bp)
Type: Others
Protein ID: WP_173409717.1
Location: 1403612..1403815 (204 bp)
Type: Toxin
Protein ID: WP_021180142.1
Location: 1403866..1404234 (369 bp)
Type: Antitoxin
Protein ID: WP_021180141.1
Location: 1404392..1404745 (354 bp)
Type: Others
Protein ID: WP_065686474.1
Location: 1407686..1407826 (141 bp)
Type: Others
Protein ID: WP_021805462.1
Location: 1407839..1408096 (258 bp)
Type: Others
Protein ID: WP_065686283.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
G9399_RS06210 (G9399_20365)1399442..1399930+489WP_173409718.1YbaY family lipoprotein-
G9399_RS06215 (G9399_20360)1399984..1400298-315WP_065686270.1MGMT family protein-
G9399_RS06225 (G9399_20350)1400679..1402466-1788WP_173409717.1adenine deaminase C-terminal domain-containing protein-
G9399_RS06230 (G9399_20345)1402603..1403529+927WP_024484393.1LysR family transcriptional regulator-
G9399_RS06235 (G9399_20340)1403612..1403815-204WP_021180142.1HHA domain-containing proteinToxin
G9399_RS06240 (G9399_20335)1403866..1404234-369WP_021180141.1Hha toxicity modulator TomBAntitoxin
G9399_RS06245 (G9399_20330)1404392..1404745-354WP_065686474.1hypothetical protein-
G9399_RS06250 (G9399_20325)1405125..1405817+693WP_161713396.1ABC transporter ATP-binding protein-
G9399_RS06255 (G9399_20320)1405817..1406674+858WP_065686281.1metal ABC transporter permease-
G9399_RS06260 (G9399_20315)1406700..1407578+879WP_173409716.1zinc ABC transporter substrate-binding protein-
G9399_RS06265 (G9399_20310)1407686..1407826-141WP_021805462.1type B 50S ribosomal protein L36-
G9399_RS06270 (G9399_20305)1407839..1408096-258WP_065686283.1type B 50S ribosomal protein L31-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8099.48 Da        Isoelectric Point: 6.9770

>T158796 WP_021180142.1 NZ_CP054160:c1403815-1403612 [Serratia fonticola]
MTKIDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Download         Length: 204 bp

>T158796 NZ_CP069841:72957-73316 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14097.78 Da        Isoelectric Point: 4.5140

>AT158796 WP_021180141.1 NZ_CP054160:c1404234-1403866 [Serratia fonticola]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNELIEHIASFVMSFKIKYMDEGDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARTFRLFSGEGVCTTMKT

Download         Length: 369 bp

>AT158796 NZ_CP069841:73316-73615 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAAACTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBU2M374

Antitoxin

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Source
ID
Structure
AlphaFold DBU2NAN4

References