Detailed information of TA system TA158793

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 2887134..2887729
• Replicon: chromosome
• Accession: NZ_CP054150
• Organism: Agrobacterium vaccinii strain B7.6

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HRR99_RS14010
• Protein ID: WP_111840494.1
• Coordinates: 2887541..2887729 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HRR99_RS14005
• Protein ID: WP_233122160.1
• Coordinates: 2887134..2887535 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRR99_RS13990 (HRR99_13955)	2882766..2885393	+	2628	WP_233122157.1	DNA translocase FtsK	-
HRR99_RS13995 (HRR99_13960)	2885562..2886227	+	666	WP_233122158.1	outer membrane lipoprotein carrier protein LolA	-
HRR99_RS14000 (HRR99_13965)	2886322..2887125	+	804	WP_233122159.1	exodeoxyribonuclease III	-
HRR99_RS14005 (HRR99_13970)	2887134..2887535	-	402	WP_233122160.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HRR99_RS14010 (HRR99_13975)	2887541..2887729	-	189	WP_111840494.1	type II toxin-antitoxin system HicA family toxin	Toxin
HRR99_RS14015 (HRR99_13980)	2887796..2888251	-	456	WP_233122161.1	cyclic nucleotide-binding domain-containing protein	-
HRR99_RS14020 (HRR99_13985)	2888339..2889022	-	684	WP_112499003.1	response regulator transcription factor	-
HRR99_RS14025 (HRR99_13990)	2889214..2889762	+	549	WP_233122162.1	L,D-transpeptidase family protein	-
HRR99_RS14030 (HRR99_13995)	2889830..2891239	-	1410	WP_233122163.1	3-isopropylmalate dehydratase large subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 6793.90 Da
• Isoelectric Point: 11.3631

>T158793 WP_111840494.1 NZ_CP054150:c2887729-2887541 [Agrobacterium vaccinii]
MRSGDVISALRAAGWYEVATKGSHVQFKHTSLPGRVTVPHPKRDLPVGTLKSIEKQSGLKLR

Nucleotide

• Length: 189 bp

>T158793 NZ_CP069829:27859-28275 [Klebsiella pneumoniae]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14308.02 Da
• Isoelectric Point: 4.2452

>AT158793 WP_233122160.1 NZ_CP054150:c2887535-2887134 [Agrobacterium vaccinii]
MRNYIGLIHKDDDSDFGVSFPDFAGVVTAGSDLDDARQMAEEALTLHVEGMVEDGEAIPEPSSLDAIMADPDNRDAVAIL
VSVKIESKKAIRLNITLPEDVLKEIDTYAQAHGLTRSGFLARAAKHEIASSPS

Nucleotide

• Length: 402 bp

>AT158793 NZ_CP069829:27632-27862 [Klebsiella pneumoniae]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA