Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1061702..1062246 Replicon chromosome
Accession NZ_CP054150
Organism Agrobacterium vaccinii strain B7.6

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HRR99_RS05355 Protein ID WP_233123041.1
Coordinates 1061923..1062246 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HRR99_RS05350 Protein ID WP_233123040.1
Coordinates 1061702..1061926 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRR99_RS05340 (HRR99_05325) 1056784..1060992 + 4209 WP_111841242.1 DNA-directed RNA polymerase subunit beta' -
HRR99_RS05345 (HRR99_05330) 1061128..1061607 + 480 WP_233123039.1 GNAT family N-acetyltransferase -
HRR99_RS05350 (HRR99_05335) 1061702..1061926 + 225 WP_233123040.1 antitoxin MazE family protein Antitoxin
HRR99_RS05355 (HRR99_05340) 1061923..1062246 + 324 WP_233123041.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HRR99_RS05360 (HRR99_05345) 1062281..1062574 - 294 WP_233123042.1 transcriptional regulator -
HRR99_RS05365 (HRR99_05350) 1063096..1063467 + 372 WP_003507760.1 30S ribosomal protein S12 -
HRR99_RS05370 (HRR99_05355) 1063546..1064016 + 471 WP_062450738.1 30S ribosomal protein S7 -
HRR99_RS05375 (HRR99_05360) 1064044..1066143 + 2100 WP_233123043.1 elongation factor G -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-103)

Antitoxin

Antitoxin MazE-like

(6-71)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11535.49 Da        Isoelectric Point: 9.9948

>T158791 WP_233123041.1 NZ_CP054150:1061923-1062246 [Agrobacterium vaccinii]
VRRGDLVTVSVSGDFGKPRPAVIVQSDYFSDTATVTVLLLSGTLVEAPFIRLTVQPSPQNGLTKPSQVMIDKSMTVLRNK
LGPVFGRLDDDMMLSITRSLAVFIGIA

Download         Length: 324 bp

>T158791 NZ_CP069821:c5051034-5050687 [Klebsiella pneumoniae]
ATGTGGGATGTGGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATAAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8265.14 Da        Isoelectric Point: 4.7683

>AT158791 WP_233123040.1 NZ_CP054150:1061702-1061926 [Agrobacterium vaccinii]
MATSVNHRVQKRRDALRASGLRPMQIWVPDTRRAGFEAECRRQSRAVAASDALDTEFDAFTDAALADLDDEVSE

Download         Length: 225 bp

>AT158791 NZ_CP069821:c5050687-5050388 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAAAGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References