Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 974738..975369 Replicon chromosome
Accession NZ_CP054150
Organism Agrobacterium vaccinii strain B7.6

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HRR99_RS04950 Protein ID WP_111839711.1
Coordinates 974971..975369 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HRR99_RS04945 Protein ID WP_111839712.1
Coordinates 974738..974971 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRR99_RS04920 (HRR99_04905) 969922..970158 + 237 WP_006727438.1 acyl carrier protein -
HRR99_RS04925 (HRR99_04910) 970301..971569 + 1269 WP_111839715.1 beta-ketoacyl-ACP synthase II -
HRR99_RS04930 (HRR99_04915) 971808..973040 + 1233 WP_111839714.1 endolytic transglycosylase MltG -
HRR99_RS04935 (HRR99_04920) 973095..973982 + 888 WP_233122987.1 YicC/YloC family endoribonuclease -
HRR99_RS04940 (HRR99_04925) 973988..974659 + 672 WP_112499179.1 guanylate kinase -
HRR99_RS04945 (HRR99_04930) 974738..974971 + 234 WP_111839712.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HRR99_RS04950 (HRR99_04935) 974971..975369 + 399 WP_111839711.1 type II toxin-antitoxin system VapC family toxin Toxin
HRR99_RS04955 (HRR99_04940) 975378..976208 - 831 WP_233122988.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
HRR99_RS04960 (HRR99_04945) 976208..977227 - 1020 WP_233122989.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
HRR99_RS04965 (HRR99_04950) 977244..978188 - 945 WP_233122990.1 peptidylprolyl isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(8-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14693.91 Da        Isoelectric Point: 6.6963

>T158789 WP_111839711.1 NZ_CP054150:974971-975369 [Agrobacterium vaccinii]
MLSYMLDTNICIYVMKTYPPELRDRFNATAEQLCISSITLGELCFGAEKSARRSENLAAIDNFVSRLDVLPFGDKAAAHY
GQIRAELSRAGTPCGVHDMQIGGHARAEGLIVVTNNMREFVRMPGLRVENWV

Download         Length: 399 bp

>T158789 NZ_CP069821:c3953431-3953015 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATTATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACCGACATCCGGGTGGCGCTGCACCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCGGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTGCCTGGACTGACACTGG
AAGACTGGGTTATTTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8814.07 Da        Isoelectric Point: 6.4632

>AT158789 WP_111839712.1 NZ_CP054150:974738-974971 [Agrobacterium vaccinii]
MTTSTVFLSNKSQAVRLPKAVAFPDDVHQVDILKIGRSRVIVPHGRRWDDLFASGPRASEDFLMEREMPLLDERESF

Download         Length: 234 bp

>AT158789 NZ_CP069821:c3953658-3953428 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAACGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References