Detailed information of TA system TA158786

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 43015..43550
• Replicon: plasmid pB19.1.4b
• Accession: NZ_CP054149
• Organism: Agrobacterium vaccinii strain B19.1.4

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HRS00_RS23690
• Protein ID: WP_233138089.1
• Coordinates: 43015..43296 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A0D0KMQ9
• Locus tag: HRS00_RS23695
• Protein ID: WP_042619849.1
• Coordinates: 43296..43550 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRS00_RS23680 (HRS00_23620)	39799..41727	-	1929	WP_233138087.1	ABC transporter substrate-binding protein	-
HRS00_RS23685 (HRS00_23625)	41934..42947	+	1014	WP_233138088.1	LacI family DNA-binding transcriptional regulator	-
HRS00_RS23690 (HRS00_23630)	43015..43296	-	282	WP_233138089.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HRS00_RS23695 (HRS00_23635)	43296..43550	-	255	WP_042619849.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
HRS00_RS23700 (HRS00_23640)	43752..44228	+	477	WP_233138090.1	VOC family protein	-
HRS00_RS23705 (HRS00_23645)	44737..45951	+	1215	WP_233138091.1	GGDEF domain-containing protein	-
HRS00_RS23710 (HRS00_23650)	46385..46753	-	369	WP_206591641.1	response regulator	-
HRS00_RS23715 (HRS00_23655)	46907..47947	-	1041	WP_103588143.1	sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..135032	135032

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Antitoxin ParD (1-77)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10644.14 Da
• Isoelectric Point: 6.2137

>T158786 WP_233138089.1 NZ_CP054149:c43296-43015 [Agrobacterium vaccinii]
MPFSLSVQAEEDIISIAEEGISIFGALVAKRYHDELFAFATNPRMARERHEISPPVRIHPFKAHLVVYRIIEDGSVFVIR
IRHGHEDWAGDSF

Nucleotide

• Length: 282 bp

>T158786 NZ_CP069821:2739135-2740457 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9380.49 Da
• Isoelectric Point: 8.5776

>AT158786 WP_042619849.1 NZ_CP054149:c43550-43296 [Agrobacterium vaccinii]
MATMNVSLPDPMKDWVEAQAKTGRYSNASDYVRDLIRRDQARTDKIAEMQRFVDDGIRSGVGGRSTEELFALATSRAAIS
RGRD

Nucleotide

• Length: 255 bp

>AT158786 NZ_CP069821:2738869-2739135 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0D0KMQ9