Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 85355..86025 Replicon plasmid pB19.1.4a
Accession NZ_CP054148
Organism Agrobacterium vaccinii strain B19.1.4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HRS00_RS22885 Protein ID WP_233137977.1
Coordinates 85606..86025 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HRS00_RS22880 Protein ID WP_233137976.1
Coordinates 85355..85609 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRS00_RS22870 (HRS00_22810) 82666..84594 + 1929 WP_277880531.1 methyl-accepting chemotaxis protein -
HRS00_RS22875 (HRS00_22815) 84594..85067 + 474 WP_233137975.1 chemotaxis protein CheW -
HRS00_RS22880 (HRS00_22820) 85355..85609 + 255 WP_233137976.1 plasmid stabilization protein Antitoxin
HRS00_RS22885 (HRS00_22825) 85606..86025 + 420 WP_233137977.1 type II toxin-antitoxin system VapC family toxin Toxin
HRS00_RS22890 (HRS00_22830) 86113..86307 - 195 WP_233137978.1 hypothetical protein -
HRS00_RS22895 (HRS00_22835) 86334..87113 + 780 WP_233137979.1 sensor histidine kinase -
HRS00_RS22900 (HRS00_22840) 87264..88064 + 801 WP_233137980.1 potassium channel family protein -
HRS00_RS22905 (HRS00_22845) 88224..89489 + 1266 WP_233137981.1 DUF2254 domain-containing protein -
HRS00_RS22910 (HRS00_22850) 89532..90815 - 1284 WP_233137995.1 sodium:proton antiporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..218909 218909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15026.29 Da        Isoelectric Point: 5.1239

>T158785 WP_233137977.1 NZ_CP054148:85606-86025 [Agrobacterium vaccinii]
MILLDTNVISEPWKPSPDIAMLTWLDAQAIETLFISAISIAELRFGIASMPSGKRQTILHDRLEGEVLPIFDGRILPFNV
GTSQFYADLMARGRTSGKAIGKADGYIAATAAENHLAVATRDTSPFEAAGLRVINPWAA

Download         Length: 420 bp

>T158785 NZ_CP069821:c1473959-1473741 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9119.24 Da        Isoelectric Point: 5.6939

>AT158785 WP_233137976.1 NZ_CP054148:85355-85609 [Agrobacterium vaccinii]
MAAVTIRNLSDETHRALRARAAYHGRSTEAEIRDILEAAVRPSGRVKLGSLLAAIGRDAEMSNSDVEALEQQRDGTPAVP
MTFE

Download         Length: 255 bp

>AT158785 NZ_CP069821:c1474360-1473986 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References