Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 997937..998460 Replicon chromosome
Accession NZ_CP054146
Organism Agrobacterium vaccinii strain B19.1.4

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag HRS00_RS04920 Protein ID WP_233136294.1
Coordinates 997937..998224 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag HRS00_RS04925 Protein ID WP_173996658.1
Coordinates 998221..998460 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRS00_RS04900 (HRS00_04890) 993644..994489 - 846 WP_233136290.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
HRS00_RS04905 (HRS00_04895) 994507..996705 + 2199 WP_233136291.1 molybdopterin oxidoreductase family protein -
HRS00_RS04910 (HRS00_04900) 996718..997314 + 597 WP_233136292.1 NUDIX domain-containing protein -
HRS00_RS04915 (HRS00_04905) 997329..997940 + 612 WP_233136293.1 NUDIX domain-containing protein -
HRS00_RS04920 (HRS00_04910) 997937..998224 - 288 WP_233136294.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRS00_RS04925 (HRS00_04915) 998221..998460 - 240 WP_173996658.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
HRS00_RS04930 (HRS00_04920) 998527..999186 - 660 WP_233136295.1 phosphoribosylglycinamide formyltransferase -
HRS00_RS04935 (HRS00_04925) 999183..1000256 - 1074 WP_233136296.1 phosphoribosylformylglycinamidine cyclo-ligase -
HRS00_RS04940 (HRS00_04930) 1000494..1001648 + 1155 WP_111839682.1 AI-2E family transporter -
HRS00_RS04945 (HRS00_04935) 1001653..1002366 + 714 WP_233123017.1 DnaA regulatory inactivator HdaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-91)

Antitoxin

Antitoxin ParD

(1-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10704.27 Da        Isoelectric Point: 9.5632

>T158781 WP_233136294.1 NZ_CP054146:c998224-997937 [Agrobacterium vaccinii]
MKALLLTPKARSDIEAIWDYTVDNWGTNQAEVYITAIQKALEGLADGSTISQSAESIRKNYRKTIVGSHTVFFKETNAAI
EVVRILHHRMSLTRL

Download         Length: 288 bp

>T158781 NZ_CP069821:228946-229329 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8820.81 Da        Isoelectric Point: 4.8550

>AT158781 WP_173996658.1 NZ_CP054146:c998460-998221 [Agrobacterium vaccinii]
MGKSTSVNLNDHFDAFIEQQIEDGRYASASEVLRAGLRLLEEREAELSHLRAALIEGEKSGDAVPFDFREFVRGKKNPG

Download         Length: 240 bp

>AT158781 NZ_CP069821:228704-228946 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References