Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 965290..965921 Replicon chromosome
Accession NZ_CP054146
Organism Agrobacterium vaccinii strain B19.1.4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HRS00_RS04760 Protein ID WP_233136271.1
Coordinates 965523..965921 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HRS00_RS04755 Protein ID WP_111839712.1
Coordinates 965290..965523 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRS00_RS04730 (HRS00_04720) 960471..960707 + 237 WP_006727438.1 acyl carrier protein -
HRS00_RS04735 (HRS00_04725) 960850..962118 + 1269 WP_111839715.1 beta-ketoacyl-ACP synthase II -
HRS00_RS04740 (HRS00_04730) 962360..963592 + 1233 WP_233136269.1 endolytic transglycosylase MltG -
HRS00_RS04745 (HRS00_04735) 963647..964534 + 888 WP_233136270.1 YicC/YloC family endoribonuclease -
HRS00_RS04750 (HRS00_04740) 964540..965211 + 672 WP_112499179.1 guanylate kinase -
HRS00_RS04755 (HRS00_04745) 965290..965523 + 234 WP_111839712.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HRS00_RS04760 (HRS00_04750) 965523..965921 + 399 WP_233136271.1 tRNA(fMet)-specific endonuclease VapC Toxin
HRS00_RS04765 (HRS00_04755) 965930..966760 - 831 WP_233136272.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
HRS00_RS04770 (HRS00_04760) 966760..967779 - 1020 WP_233136273.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
HRS00_RS04775 (HRS00_04765) 967796..968740 - 945 WP_233122990.1 peptidylprolyl isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(8-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14725.95 Da        Isoelectric Point: 6.6963

>T158780 WP_233136271.1 NZ_CP054146:965523-965921 [Agrobacterium vaccinii]
MLSYMLDTNICIYVMKTYPLELRDRFNATAEQLCISSITLGELCFGAEKSARRSENLAAIDNFVSRLDVLPFGDKAAAHY
GQIRAELSRAGTPCGVHDMQIGGHARSEGLIVVTNNMREFVRMPGLRVENWV

Download         Length: 399 bp

>T158780 NZ_CP054146:965523-965921 [Agrobacterium vaccinii]
ATGCTTTCCTATATGCTCGATACCAATATCTGCATCTACGTGATGAAGACCTATCCTCTCGAACTCAGGGATAGATTCAA
TGCCACCGCAGAGCAGCTTTGCATTTCGAGTATTACGCTGGGTGAGCTTTGTTTCGGCGCTGAAAAATCGGCGCGCCGCA
GTGAAAACCTTGCCGCCATCGATAATTTCGTATCGAGGCTGGACGTACTCCCCTTCGGCGATAAAGCGGCTGCCCACTAC
GGACAAATCCGGGCTGAATTGTCGCGCGCAGGAACACCTTGTGGCGTTCACGACATGCAGATCGGTGGACACGCGCGCTC
GGAGGGTCTGATCGTTGTCACAAACAATATGCGGGAATTCGTCCGAATGCCCGGCCTACGGGTCGAGAACTGGGTCTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8814.07 Da        Isoelectric Point: 6.4632

>AT158780 WP_111839712.1 NZ_CP054146:965290-965523 [Agrobacterium vaccinii]
MTTSTVFLSNKSQAVRLPKAVAFPDDVHQVDILKIGRSRVIVPHGRRWDDLFASGPRASEDFLMEREMPLLDERESF

Download         Length: 234 bp

>AT158780 NZ_CP054146:965290-965523 [Agrobacterium vaccinii]
ATGACCACGTCCACGGTATTCCTCAGTAATAAAAGTCAGGCCGTACGGCTGCCGAAGGCAGTTGCATTTCCCGACGACGT
TCATCAGGTCGACATACTGAAAATTGGACGAAGTCGAGTTATTGTTCCCCACGGGCGCCGCTGGGACGATCTCTTCGCGT
CTGGCCCCCGTGCCAGCGAAGATTTTCTCATGGAACGTGAAATGCCGCTTCTTGATGAGCGCGAGTCTTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References