Detailed information of TA system TA158779

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF-MazE
• Location: 778094..778719
• Replicon: chromosome
• Accession: NZ_CP054146
• Organism: Agrobacterium vaccinii strain B19.1.4

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: HRS00_RS03785
• Protein ID: WP_233136152.1
• Coordinates: 778360..778719 (+)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: HRS00_RS03780
• Protein ID: WP_233136151.1
• Coordinates: 778094..778360 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRS00_RS03755 (HRS00_03740)	773128..773946	+	819	WP_233136146.1	class D beta-lactamase	-
HRS00_RS03760 (HRS00_03745)	773954..774700	-	747	WP_233136147.1	hypothetical protein	-
HRS00_RS03765 (HRS00_03750)	774844..777345	+	2502	WP_233136148.1	heavy metal translocating P-type ATPase	-
HRS00_RS03770 (HRS00_03755)	777342..777752	+	411	WP_233136149.1	Cu(I)-responsive transcriptional regulator	-
HRS00_RS03775 (HRS00_03760)	777779..777979	+	201	WP_233136150.1	heavy-metal-associated domain-containing protein	-
HRS00_RS03780 (HRS00_03765)	778094..778360	+	267	WP_233136151.1	PbsX family transcriptional regulator	Antitoxin
HRS00_RS03785 (HRS00_03770)	778360..778719	+	360	WP_233136152.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
HRS00_RS03790 (HRS00_03775)	778728..778916	+	189	WP_233136153.1	hypothetical protein	-
HRS00_RS03795 (HRS00_03780)	778932..779180	-	249	WP_045231187.1	hypothetical protein	-
HRS00_RS03800 (HRS00_03785)	779335..780735	+	1401	WP_233136572.1	MFS transporter	-
HRS00_RS03805 (HRS00_03790)	780730..780900	-	171	WP_164470675.1	hypothetical protein	-
HRS00_RS03810 (HRS00_03795)	780967..782682	-	1716	WP_045231186.1	GH32 C-terminal domain-containing protein	-
HRS00_RS03815 (HRS00_03800)	782962..783708	+	747	WP_233136154.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 12857.11 Da
• Isoelectric Point: 8.7990

>T158779 WP_233136152.1 NZ_CP054146:778360-778719 [Agrobacterium vaccinii]
MVRSNVPKRGDVFLIDLNPVVGNEMKDEHRCVVITPKEINAVGLCLVVPITTGGMFTRKAGLAVNISGHRTTGVALCSQV
RSLDIAGRIAQKRAKFLETLDDATMQEIVARVVSMIDPA

Nucleotide

• Length: 360 bp

>T158779 NZ_CP069820:c650905-650654 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9428.91 Da
• Isoelectric Point: 4.4297

>AT158779 WP_233136151.1 NZ_CP054146:778094-778360 [Agrobacterium vaccinii]
MTVTTKIRRQGGAAVMTIPPALLKLMGTEIGSEMTLEIDNGILVASPVTTQKKRYSLEELLEGADEMAELNVEASAWDAA
PRVGKEAL

Nucleotide

• Length: 267 bp

>AT158779 NZ_CP069820:c650651-650250 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA