Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 741215..741801 Replicon chromosome
Accession NZ_CP054146
Organism Agrobacterium vaccinii strain B19.1.4

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HRS00_RS03565 Protein ID WP_233136118.1
Coordinates 741541..741801 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HRS00_RS03560 Protein ID WP_233136117.1
Coordinates 741215..741544 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRS00_RS03540 (HRS00_03520) 736608..738707 - 2100 WP_233136114.1 S9 family peptidase -
HRS00_RS03545 (HRS00_03525) 738944..739345 + 402 WP_045231283.1 DUF930 domain-containing protein -
HRS00_RS03550 (HRS00_03530) 739506..740426 + 921 WP_233136115.1 dihydrodipicolinate synthase family protein -
HRS00_RS03555 (HRS00_03535) 740482..741207 + 726 WP_233136116.1 polysaccharide deacetylase family protein -
HRS00_RS03560 (HRS00_03540) 741215..741544 - 330 WP_233136117.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HRS00_RS03565 (HRS00_03545) 741541..741801 - 261 WP_233136118.1 type II toxin-antitoxin system HicA family toxin Toxin
HRS00_RS03570 (HRS00_03550) 741903..743069 - 1167 WP_233136119.1 AI-2E family transporter -
HRS00_RS03575 (HRS00_03555) 743180..744040 - 861 WP_233136120.1 VOC family protein -
HRS00_RS03580 (HRS00_03560) 744244..744654 + 411 WP_233136121.1 universal stress protein -
HRS00_RS03585 (HRS00_03565) 744789..745457 + 669 WP_233136122.1 hemolysin III family protein -
HRS00_RS03590 (HRS00_03570) 745546..746049 + 504 WP_233136123.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-84)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9449.88 Da        Isoelectric Point: 10.6545

>T158778 WP_233136118.1 NZ_CP054146:c741801-741541 [Agrobacterium vaccinii]
MELGKRHRAVLDAIYADPVRAGIAWRDIEALFVSCGAEVTEGQGSRVRVALNGVRAVFHRPHPQKETDKGAVKSVRRFLS
EAGIKP

Download         Length: 261 bp

>T158778 NZ_CP069815:4674186-4674554 [Raoultella planticola]
ATGAAAACCCTACCTGCTATAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGTTACTTAC
TCGTCTGCTTGAGCAGCACTATGGCCTAATGCTAAGCGACACGCCTTTTAGCGATGAAACCGTTATAAAGGAGCATATCG
ATGCCGGTATCACTCTGGCTAATGCCGTTAACTTTCTGGTAGAGAAATATGAGTTAGTTCGTATTGATCGTAATGGATTT
ACCTCTCAGGTACAAGCACCATATTTGACTGCGACAGACATTCTTCAAGCCAGGAAAGCGTGCGGGCTGATGAGCCGGTG
TTCTTACAGGGAGGTAAGTAATATTGTTCTTAGCCGATCACGGCTGTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12108.60 Da        Isoelectric Point: 4.5117

>AT158778 WP_233136117.1 NZ_CP054146:c741544-741215 [Agrobacterium vaccinii]
MSVMHYKGYEAIIEFDEDADIFHGEVIDLKDIITFQGTSAAELKQALADSVEDYLSFCAERGEEPEKPFSGQFVVRTEPK
LHKAVSNAARKDGVSLNKWVTAALERAVS

Download         Length: 330 bp

>AT158778 NZ_CP069815:4673848-4674165 [Raoultella planticola]
ATGAGTAACACCACATGGGGCCTGCAGAGGGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCGGCT
GCACTATCTCGATGACCGGGCCAGTATCACCGGTAAGTTTAGTGATGCCCAATGTATTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGGTGCTGACCACTGGCGAACTGAATCCCCGTCATGCCCACTGCGTTACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCCATTTATCCCACTCAGCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References