Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 486008..486642 Replicon chromosome
Accession NZ_CP054142
Organism Treponema parvum strain ATCC 700770

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HRQ91_RS02300 Protein ID WP_210120073.1
Coordinates 486008..486412 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HRQ91_RS02305 Protein ID WP_210120074.1
Coordinates 486412..486642 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRQ91_RS02270 (HRQ91_02275) 481214..481732 + 519 WP_210120069.1 TRAP transporter small permease -
HRQ91_RS02275 (HRQ91_02280) 481765..483048 + 1284 WP_210120070.1 TRAP transporter large permease -
HRQ91_RS02280 (HRQ91_02285) 483187..483399 + 213 WP_210120071.1 type II toxin-antitoxin system VapB family antitoxin -
HRQ91_RS02285 (HRQ91_02290) 483656..484711 + 1056 WP_210117137.1 NAD(P)-dependent alcohol dehydrogenase -
HRQ91_RS02290 (HRQ91_02295) 485061..485240 + 180 WP_246473258.1 toxin-antitoxin system HicB family antitoxin -
HRQ91_RS02295 (HRQ91_02300) 485414..485827 + 414 WP_210120072.1 hypothetical protein -
HRQ91_RS02300 (HRQ91_02305) 486008..486412 - 405 WP_210120073.1 type II toxin-antitoxin system VapC family toxin Toxin
HRQ91_RS02305 (HRQ91_02310) 486412..486642 - 231 WP_210120074.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HRQ91_RS02310 (HRQ91_02315) 487000..487470 + 471 WP_210120075.1 hypothetical protein -
HRQ91_RS02315 (HRQ91_02320) 487467..488390 + 924 WP_210120076.1 M48 family metallopeptidase -
HRQ91_RS02320 (HRQ91_02325) 488394..490484 + 2091 WP_210120077.1 adenylate/guanylate cyclase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15443.59 Da        Isoelectric Point: 4.4210

>T158776 WP_210120073.1 NZ_CP054142:c486412-486008 [Treponema parvum]
MYLLDTNICIFLIKNKFPNLTEKILAFDSKELFLSSVSIAEMEYGASKSQNREKNRQALLDFCADFENILDFTTDDTEAY
GLIRAYLEKEGKIIGSYDMQIAAQAMTRNLTVVTNNYDEFGRIPWIKVEDWSKA

Download         Length: 405 bp

>T158776 NZ_CP069815:c4377935-4377546 [Raoultella planticola]
ATGCAAACCAAATCATCCCCCCTCATGCGGGCGGCATCGTCACGTCCGTCTCCGGTGAGTGTCTGGCAGACCCTGCTGAC
CAGCCTGCTGGCACAACACTATGGCCTCACGCTTAGCGATACGCCGTTCAGTGATGAACAGGTCATTCAGCAACATATTG
ATGCCGGTATCTCGCTGGTTGATGCCCTGAATTTTATCGTTGAGAAGTATGAACTGGTCCGCACTGACCGCCCAGGCTTC
AGCATCCTGACGCAGTCTCCGTTTATCACACCCATAGATATCCTCCGGGCCAGGAAAGCAACGGGGCTGATGAACCGTGA
CACGTATAAAGAGGTGACGGCTATTACCAGAGGGCAACATCCGCAGGTCAGCGCTCCAGGCAAGCGATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 9023.26 Da        Isoelectric Point: 9.8135

>AT158776 WP_210120074.1 NZ_CP054142:c486642-486412 [Treponema parvum]
MVRTKVFTSGNSQAVRIPKEFHIDHSELFIKKIGTTIILYPRNKPWENLQKSFSEFTDDFMSEGRNQPKFQAREEF

Download         Length: 231 bp

>AT158776 NZ_CP069815:c4378318-4377992 [Raoultella planticola]
ATCAGCGAACCCTGGTGGGGGCTCAGGCGAAGTGTCTCCCCGTGTTTTGGGGCCCGTCTGGTCCAGGAGGGAAACCGCCT
GCATTACCTGGCTGACCGGGCGAATGTTAGCGGACAGTTCTGTGATGCGGATTTACGCCATCTTGACCAGGCTTTCCCGA
TATTGCTCAAACAGCTGGAGTTAATGCTCACCAGCGGTGAACTGAATCCCCGTCATCAGCACTGCGTCACGCTGTATGCA
AAAGGTCTGACCTGCGAGGCCGATACGCTCGGTTCGCACGGCTATGTTTATATCGCGATTTATCCCACTCCTGTCGCCAC
GGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References