Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 273956..274506 Replicon chromosome
Accession NZ_CP054142
Organism Treponema parvum strain ATCC 700770

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HRQ91_RS01225 Protein ID WP_210117298.1
Coordinates 274225..274506 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HRQ91_RS01220 Protein ID WP_210117299.1
Coordinates 273956..274228 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRQ91_RS01200 (HRQ91_01205) 270541..271149 + 609 WP_210119908.1 hypothetical protein -
HRQ91_RS01205 (HRQ91_01210) 271146..271925 + 780 WP_210119909.1 ABC transporter permease -
HRQ91_RS01210 (HRQ91_01215) 271912..272625 + 714 WP_210117301.1 ABC transporter ATP-binding protein -
HRQ91_RS01215 (HRQ91_01220) 272652..273584 + 933 WP_210119910.1 NrtA/SsuA/CpmA family ABC transporter substrate-binding protein -
HRQ91_RS01220 (HRQ91_01225) 273956..274228 + 273 WP_210117299.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HRQ91_RS01225 (HRQ91_01230) 274225..274506 + 282 WP_210117298.1 type II toxin-antitoxin system YafQ family toxin Toxin
HRQ91_RS01230 (HRQ91_01235) 274532..275173 + 642 WP_210119911.1 alpha/beta hydrolase -
HRQ91_RS01235 (HRQ91_01240) 275160..275480 + 321 WP_210119912.1 TfoX/Sxy family protein -
HRQ91_RS01240 (HRQ91_01245) 275670..275936 - 267 WP_210119913.1 hypothetical protein -
HRQ91_RS01245 (HRQ91_01250) 276067..277260 - 1194 WP_210119914.1 IS256 family transposase -
HRQ91_RS01250 (HRQ91_01255) 277340..277588 - 249 WP_210119915.1 hypothetical protein -
HRQ91_RS01255 (HRQ91_01260) 277625..277948 - 324 WP_210119916.1 type II toxin-antitoxin system RelE/ParE family toxin -
HRQ91_RS01260 (HRQ91_01265) 277952..278272 - 321 WP_210119917.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HRQ91_RS01265 (HRQ91_01270) 278823..279062 + 240 WP_210117294.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HRQ91_RS01270 (HRQ91_01275) 279059..279454 + 396 WP_210119918.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(2-88)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11020.83 Da        Isoelectric Point: 10.1013

>T158775 WP_210117298.1 NZ_CP054142:274225-274506 [Treponema parvum]
MKYEVKFTTQFKKDIKRAEKQNRNLNKLFGVIDLLVHGKPLEAKYRDHALSGKYKGTRECHIDPDWLLVYEHLNDVLVLM
LHRAGSHSELFRK

Download         Length: 282 bp

>T158775 NZ_CP069815:c2887198-2885867 [Raoultella planticola]
ATGGCTACTCTCGTGACATGGATGAACAATGAGCGAGTCGGCGAACTTATCAAGCAGGCGAACGGCGCCCATCTCTTTCG
CTATGAAGAGGCGTGGATGCGCAATCCTCGCGCCAGGCCGCTCTCTCTGTCGCTCCCGCTGCAGTACGGTAACATCACCG
ACGATGCGGTGTTTAACTATTTTGACAACCTGCTGCCGGACAGCCCGCGGGTGCGGGACCGCATTGTTAAGCGCTATCAG
GCGCGTTCAAAGCAGCCTTTTGATCTGCTGGCCGAGATCGGACGCGACAGCGTCGGGGCGGTCACGTTACTCCCGCCAGG
GGAAAATGCAACCCGGGGGGCGTTGAGCTGGGAGGCGCTGGATAGCCACGCCCTGGATGCGCTGCTGACGGCCTACCAGT
CGGATATACCGCTCGGGATGGTCAACGAACACGATGATTTCAGGATCTCGGTGGCCGGGGCCCAGGAGAAAACCGCGCTG
CTGAAAATCGGCGAGCAGTGGTGTATACCGACGGGGACCACGCCGACCACCCATATCATTAAACTGCCTATCGGCGAGAT
CAAACAGCCGGATGCGGTGCTGGATCTCAGCGAAAGCGTAGATAACGAATATTTGTGTCTGGCGCTGGCCCGGGCGCTGG
GTTTTGCCGTTCCGCGCGCCAGCATTATCCAGACCGCCAGCATCAGGGCGCTGGCGGTTGAGCGTTTCGACCGTCGTTGG
GCGCAGGAGAAGACGGTGCTGCTGCGTTTACCGCAGGAAGATCTGTGTCAGGCCTTCGGCATTCCGTCATCGATTAAGTA
TGAGTCCGACGGCGGGCCGGGCATTCGGGCGATTATGGCTTTTCTGGTTGGATCCAGCGAGGCGCTCGAGGATCGCTATA
ACTTTATGAAGTTTATGGTGTTCCAGTGGCTGATTGGCGCAACCGATGGCCACGCGAAAAACTTCTCGATCTTCCTCCAG
CCGGGCGGCAGCTATCGCTTAACCCCATTCTACGACATTATCTCCGCGTTTCCGCTGCTTGGCGGGAAGGGGCTGCACCT
GAGCGATCTCCGGCTGTCAATGAGCCTGAAGGCCAGTAAAGGGCGCAAAACGGAGATCCAGACGCTCTATCCGCGTCATT
TCCTCGCCACGGCGAAAGAGGTGGGGTTTGCCGAGGAGCAGATGCTGGAGATTCTGCGCTATTTTGTCGATAACGTTCCC
CACGCGGTTGCTGCGGTAAAGGAAACTTTACCGCATGACTTTTCACCACCGGTGTATGAGGCGATCACCGATCGCTTACT
GTGGGTCCATTCACGCTTGCAGAACGCAATGGCGGCGTTACCGTCGGGCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10032.42 Da        Isoelectric Point: 5.0941

>AT158775 WP_210117299.1 NZ_CP054142:273956-274228 [Treponema parvum]
VTTTNLNIRTDKDIKDRAEALFSELGLTMTAAVNMFLRTALRENGIPFTLRLDIPNNLTESAITEGRKIAYDDSVKGYSN
ISDLRKALEV

Download         Length: 273 bp

>AT158775 NZ_CP069815:c2887470-2887198 [Raoultella planticola]
ATGAGCCCTTCACCAGGAATATACAGCCCGGTTCAGCTGGCAAACTATCTCAAGCTGGTGCGCCAGAAAAACCAGTGGAC
GCAGAGCGACCTGGCTCAGCGTATGGGGATTAAACAGGCTACCGTCTCTAACTTTGAAAATCATCCCGAGAAAACGACGT
TAACCACGGTGTTTAAAATTTTACAGTCACTGGAACTGTCGATGGCGATTTGCGAAAAAAATGCGCCGGATACCAACGAT
AGCAGTGATAACCCACAGGATCTGGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References