Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 254660..255225 Replicon chromosome
Accession NZ_CP054142
Organism Treponema parvum strain ATCC 700770

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HRQ91_RS01120 Protein ID WP_210119892.1
Coordinates 254660..254998 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HRQ91_RS01125 Protein ID WP_210119893.1
Coordinates 254992..255225 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRQ91_RS01100 (HRQ91_01105) 250127..251182 - 1056 WP_210119889.1 extracellular solute-binding protein -
HRQ91_RS01105 (HRQ91_01110) 251290..252963 - 1674 WP_210119890.1 iron ABC transporter permease -
HRQ91_RS01110 (HRQ91_01115) 253053..254174 - 1122 WP_210119891.1 ABC transporter ATP-binding protein -
HRQ91_RS01115 (HRQ91_01120) 254380..254538 - 159 Protein_219 Txe/YoeB family addiction module toxin -
HRQ91_RS01120 (HRQ91_01125) 254660..254998 - 339 WP_210119892.1 endoribonuclease MazF Toxin
HRQ91_RS01125 (HRQ91_01130) 254992..255225 - 234 WP_210119893.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HRQ91_RS01130 (HRQ91_01135) 255454..255966 + 513 WP_210119894.1 ClbS/DfsB family four-helix bundle protein -
HRQ91_RS01135 (HRQ91_01140) 256220..256390 + 171 WP_210119895.1 hypothetical protein -
HRQ91_RS01140 (HRQ91_01145) 256525..257238 + 714 WP_210119896.1 MmcQ/YjbR family DNA-binding protein -
HRQ91_RS01145 (HRQ91_01150) 257325..258383 + 1059 WP_210119897.1 iron ABC transporter permease -
HRQ91_RS01150 (HRQ91_01155) 258380..259168 + 789 WP_210119898.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-110)

Antitoxin

Antitoxin PemI-like

(3-77)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12835.70 Da        Isoelectric Point: 6.2144

>T158774 WP_210119892.1 NZ_CP054142:c254998-254660 [Treponema parvum]
MVNSNYVPEKGDLVWLDFDPQTGHEQKGRRPAICISHKSYNQKIGLALFCPITSRIKGYPFEIVLNQHSINGCILSDQIK
NLDWKQRSCDFIEKAADEEIDSVVQNIKLMIE

Download         Length: 339 bp

>T158774 NZ_CP069815:2145317-2145420 [Raoultella planticola]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8693.02 Da        Isoelectric Point: 7.2011

>AT158774 WP_210119893.1 NZ_CP054142:c255225-254992 [Treponema parvum]
VQTIVHKWGNSLGFRIPSLWAKDNDIKNGSKVEVIIEKGKIVILPQKKSLDYMLALVNEENIHSEVSTGYAVGKEEW

Download         Length: 234 bp

>AT158774 NZ_CP069815:c2145425-2145259 [Raoultella planticola]
CAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTTACCGCGTCAGGTTTTCCAGTCCGCAACAAAAGTGGT
CGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References