Detailed information of TA system TA158773

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2177120..2177713
• Replicon: chromosome
• Accession: NZ_CP054140
• Organism: Desulfobulbus oligotrophicus strain Prop6

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HP555_RS09910
• Protein ID: WP_199264538.1
• Coordinates: 2177120..2177311 (+)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HP555_RS09915
• Protein ID: WP_199262023.1
• Coordinates: 2177321..2177713 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HP555_RS09885	2172314..2172874	-	561	WP_199262015.1	sugar O-acetyltransferase	-
HP555_RS09890	2172945..2173499	-	555	WP_199262017.1	hypothetical protein	-
HP555_RS09895	2173574..2174113	-	540	WP_199262019.1	GNAT family N-acetyltransferase	-
HP555_RS09900	2174363..2174662	-	300	WP_199262021.1	GIY-YIG nuclease family protein	-
HP555_RS09905	2175080..2176162	-	1083	WP_199261908.1	IS5 family transposase	-
HP555_RS09910	2177120..2177311	+	192	WP_199264538.1	type II toxin-antitoxin system HicA family toxin	Toxin
HP555_RS09915	2177321..2177713	+	393	WP_199262023.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HP555_RS09925	2178237..2180753	-	2517	WP_199262025.1	ATP-dependent helicase HrpB	-
HP555_RS09930	2180929..2182155	+	1227	WP_199262027.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-62)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-125)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7190.40 Da
• Isoelectric Point: 11.7888

>T158773 WP_199264538.1 NZ_CP054140:2177120-2177311 [Desulfobulbus oligotrophicus]
ITTMNSRQLIKQLEADGWILVRVKRSHHQFKHPVKPGLVTVKHPNSDIPAGTLNNIRKQAGWK

Nucleotide

• Length: 192 bp

>T158773 NZ_CP069815:955997-956407 [Raoultella planticola]
GTGGTCCTGTGGCAATCTGATTTACGCATTTCCTGGCGCTCGCAGTGGTTCTCGCTGCTGCTGCACGGCATTGTGGCGGC
GATTGTCCTGCTGATGCCCTGGCCGCTGAGCTACACACCGCTATGGCTATTGCTGCTGTCGCTGGTGGTGTTCGACAGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCGGGGGGAAATAAAGCTGATGACCGATTCGCGTTTGCGTTGGCAAAAAGCG
GAATGGGAAATTGTCGGCACGCCGTGGGTGATTAATAGCGGGATGTTGCTGCGCCTGCAGGATATGCAAACGCGTCGCCG
CCAGCATCTGTGGGTCGCTGCAGACAGTATGGACGCCAAAGAGTGGCGAGATCTGCGCCGGTTGGTTTTACAAAAACCGG
CACAGGATTAA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 14050.82 Da
• Isoelectric Point: 4.7378

>AT158773 WP_199262023.1 NZ_CP054140:2177321-2177713 [Desulfobulbus oligotrophicus]
MRFPVVLHTDDGIHFGVTVPDLPGCFSGGDTFDEALDSVLEAIDLHLEGVVEEGGEIPVPRPIADHQSNPDFANGVWAVV
DVNVSRFEGKAEKINITLPRRLLAKIDSYAQAHGKTRSGFLADAARSAMR

Nucleotide

• Length: 393 bp

>AT158773 NZ_CP069815:955750-956016 [Raoultella planticola]
ATGGACATTACGAATAAAGCCCGCATCCACTGGGCATGCCGCAGGGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTCGAGTATGAATACGATACGCTCAGCGATGAAGACAAACAGCTGTTTATCCGTCTGTTAGAAAACGACGATCCGGACC
TGTTTAACTGGCTGATGAATCATGGCGAACCGGCTGATGCACAACTGCAACGGATGGTAAAATTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA