Detailed information of TA system TA158771

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 491700..492301
• Replicon: chromosome
• Accession: NZ_CP054140
• Organism: Desulfobulbus oligotrophicus strain Prop6

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: HP555_RS02225
• Protein ID: WP_199263594.1
• Coordinates: 491960..492301 (+)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: HP555_RS02220
• Protein ID: WP_199263593.1
• Coordinates: 491700..491960 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HP555_RS02205	487488..488678	+	1191	WP_199263591.1	tetratricopeptide repeat protein	-
HP555_RS02210	489065..490399	-	1335	WP_199263592.1	IS5 family transposase	-
HP555_RS02215	490656..491552	+	897	WP_199264466.1	IS3 family transposase	-
HP555_RS02220	491700..491960	+	261	WP_199263593.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
HP555_RS02225	491960..492301	+	342	WP_199263594.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
HP555_RS02240	493964..495232	-	1269	WP_199263596.1	glucose-1-phosphate adenylyltransferase	-
HP555_RS02245	495229..496482	-	1254	WP_199263597.1	glucose-1-phosphate adenylyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-109)

Antitoxin

• Antitoxin PemI-like (1-86)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12443.54 Da
• Isoelectric Point: 9.7520

>T158771 WP_199263594.1 NZ_CP054140:491960-492301 [Desulfobulbus oligotrophicus]
MKKYIPNRGDVVWTDFDPAAGHEQMGKRPTLVLSPKAFNKTVQLAMVAPITSRIRGHAFEVPLVGKKITGVALCHQVKMI
DFVARGVQFAENAQDEVVSEVLAKVRAIISETE

Nucleotide

• Length: 342 bp

>T158771 NZ_CP069812:c2042610-2042191 [Cupriavidus oxalaticus]
ATGATTGTCTTGGATACGAATGTCGTCTCCGAGGCGATGAAGCCCGAACCTAGCCCGGCCGTGCAAGCTTGGTTGAATGA
GCAGGTAGCGGAAACCCTCTACCTGTCCAGCGTGACGCTGGCCGAACTGCTGTTCGGCATCGGCGCGCTGCCGAACGGGA
AACGTAAGAAAGGCCTGGGCGAAGCCCTGGACGGCTTGCTCGAACTGTTCGGCGAGCGGGTGCTGATGTTCGACACCGAA
GCAGCTCGCCATTATGCCGAGCTGGCGGCGAAGGCCCGCACAGCCGGGAAGGGTTTTCCAACACCCCACGGATATATTGG
GGCTATTGCGGCTTCCAAGGGATTTATCGTAGCAACACGCGACACCAGCCCTTTCGAAGCCGCTGGGCTTACTGTTATCA
ATCCTTGGAACCATCAGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9630.18 Da
• Isoelectric Point: 4.8145

>AT158771 WP_199263593.1 NZ_CP054140:491700-491960 [Desulfobulbus oligotrophicus]
MQLVVKKWGNSLGVRIPKSIAEAGKLRVDQEISIEAVDGKIVITPVIQTKEYSLKELLSGCSPKLLALDDENRQWLDDEP
VGKEIW

Nucleotide

• Length: 261 bp

>AT158771 NZ_CP069812:c2042861-2042607 [Cupriavidus oxalaticus]
ATGGCAATCCTGACAGTGCGGAATGTGCCCGATGAGGTGCATCGCGCGCTGCGCTTACGGGCCGCCGAGCATGGCCGCAG
TACAGAGGCGGAGGTGCGCGCGATTCTGGAAAGTGCAGTGAAGTCGGAAAAGCGCATCCGCATGGGCGACGCTCTGGCGG
AGCTTGGCCGTCGCGTAGGGCTGACAAACGATGATTTTGCAGTGTTGGACCAGGTGCGCGACAAGGTGCCGGCAGAACCC
ATGAGGTTTGAATGA