Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 905172..906913 Replicon chromosome
Accession NZ_CP054137
Organism Acinetobacter pittii strain JXA13

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag HRJ47_RS04325 Protein ID WP_128202435.1
Coordinates 905172..905828 (+) Length 219 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag HRJ47_RS04330 Protein ID WP_032009705.1
Coordinates 905828..906913 (+) Length 362 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRJ47_RS04320 903774..904766 - 993 WP_005028482.1 IS5-like element ISAba23 family transposase -
HRJ47_RS04325 905172..905828 + 657 WP_128202435.1 DUF4433 domain-containing protein Toxin
HRJ47_RS04330 905828..906913 + 1086 WP_032009705.1 macro domain-containing protein Antitoxin
HRJ47_RS04335 907361..908143 - 783 WP_068614383.1 SDR family oxidoreductase -
HRJ47_RS04340 908143..908466 - 324 WP_086399749.1 nuclear transport factor 2 family protein -
HRJ47_RS04345 908574..909476 + 903 WP_086399750.1 LysR family transcriptional regulator -
HRJ47_RS04350 910071..910949 + 879 WP_002118503.1 hypothetical protein -
HRJ47_RS04355 911191..911904 + 714 WP_032064107.1 DUF4882 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 903774..904766 992


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(18-218)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 219 a.a.        Molecular weight: 25338.97 Da        Isoelectric Point: 7.4752

>T158765 WP_128202435.1 NZ_CP054137:905172-905828 [Acinetobacter pittii]
MVGRNYSHVLNPQKALIWRIVHRDNIPWILENGLHSSNSPTQCVNWVQIGSPELIEKRQLHPVPVGKKGVLSDYIPFYFT
PFSPMLLNIKSGRGGVRQRTNDEIVILVSSLYQLQQQQIPFVFTNSHAYYQWAEFYTDLSSLNEIDWSILQARDFKRDMD
DPAKFERYQAEALVHQHCPTKVLIGVICYTETVKAQIEQWLQQADVNIPVHVRQGVYF

Download         Length: 657 bp

>T158765 NZ_CP069810:c3623453-3623157 [Cupriavidus oxalaticus]
ATGGAGAAGGGGACGGCGCATTACCCGCTGTGGCGGGTGCGGGAGTTGATTGCTGGCGGGTTGGTCAACTTGACTACATC
GGCCTTTGAGGGTGCGAGAAACATGTCACTTACTCGCGCCGACGTGCTCGACGTAGTGGCTGGACTGCAACCGGCTGACT
TCTACAAGAGCATGACGACCTACACCGACCATACCGTTTGGCAGGATGTATATCGGCCGAGTACGCCGTATGGGTCAATT
TATCTCAAGCTGACGGTTGTTGAAAAAGTCCTGATCGTGTCCTTCAAGGCCCGCTAG

Antitoxin


Download         Length: 362 a.a.        Molecular weight: 41091.25 Da        Isoelectric Point: 6.0689

>AT158765 WP_032009705.1 NZ_CP054137:905828-906913 [Acinetobacter pittii]
MIRYTTGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPKNMAAYSQACKAGQVTTGKMFVTETNELMGARWIINFPTK
QHWRDKSKLQWIEDGLQDLKKFIIDHQVKSIAIPPLGAGNGGLEWSRVKSKIETELSDLEYVDILIFEPTTQYQNVAKKI
GVSQLTPARAMIAELVRRYWVLGIECSLLEIQKLAWFLQRVIEQKQLPNELKLNFQANYYGPYASNLDHLLNAMDGSYLK
SDKRIPDCDPLDVIWFNDQQKSKVQGYLISEAKEYMVAVEGAATLIEGFESPFGMELLATVDWLIYKEGYQPNVESIQEG
LANWSAGERWARRKSDLFKAEHIQFALQKLDGFAYFHTDVT

Download         Length: 1086 bp

>AT158765 NZ_CP069810:c3623130-3622729 [Cupriavidus oxalaticus]
ATGCAATGCCCAGTCTGCGGTGGCGCCAAGCTCGAGAGGCGCCGTAAGGATTTCGTATACACATACCGGGGTGAGTCCAC
AGTTTTCGAAGCCGTGCTTGCCGATTGGTGCCCGAAGTGCGGGGAAGGAGTCCTGGATGCGGAAGAAGAAGAGCGGATCG
GGCCACTTGCGCTTGCGTTCAACAAACAGGTCAATGCGTCGCTGATAGACCCGGCGTACATTACCGGGGTACGCAAGAAA
CTTCGCCTGGACCAGCGCGAGGCGGCCGAGATCTTTGGCGGCGGCGTCAATGCATTCTCGCGCTACGAGACGGGCAAAAC
CAAACCCCCGCTCGCGCTGGTCAAGCTGTTGAAACTGCTCGACCGCCACCCGGAACTGCTCGAAGAAGTCCGGGCGGCCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References