Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 549023..549659 Replicon chromosome
Accession NZ_CP054136
Organism Bacillus altitudinis strain 11-1-1

Toxin (Protein)


Gene name mazF Uniprot ID K2MHT4
Locus tag HRJ37_RS02620 Protein ID WP_003214169.1
Coordinates 549309..549659 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag HRJ37_RS02615 Protein ID WP_003214273.1
Coordinates 549023..549304 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRJ37_RS02595 545177..545782 - 606 WP_007496491.1 rhomboid family intramembrane serine protease -
HRJ37_RS02600 545877..546242 + 366 WP_041092976.1 holo-ACP synthase -
HRJ37_RS02605 546403..547419 + 1017 WP_007496489.1 outer membrane lipoprotein-sorting protein -
HRJ37_RS02610 547547..548728 + 1182 WP_173407786.1 alanine racemase -
HRJ37_RS02615 549023..549304 + 282 WP_003214273.1 hypothetical protein Antitoxin
HRJ37_RS02620 549309..549659 + 351 WP_003214169.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
HRJ37_RS02625 549774..550604 + 831 WP_058336383.1 STAS domain-containing protein -
HRJ37_RS02630 550609..550977 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
HRJ37_RS02635 550980..551381 + 402 WP_003214085.1 anti-sigma regulatory factor -
HRJ37_RS02640 551392..552399 + 1008 WP_017358394.1 PP2C family protein-serine/threonine phosphatase -
HRJ37_RS02645 552459..552788 + 330 WP_017358393.1 anti-sigma factor antagonist -
HRJ37_RS02650 552785..553273 + 489 WP_017358392.1 anti-sigma B factor RsbW -
HRJ37_RS02655 553239..554027 + 789 WP_012009000.1 RNA polymerase sigma factor SigB -
HRJ37_RS02660 554027..554626 + 600 WP_173407787.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.99 Da        Isoelectric Point: 5.1663

>T158763 WP_003214169.1 NZ_CP054136:549309-549659 [Bacillus altitudinis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

>T158763 NZ_CP069810:c1849085-1847757 [Cupriavidus oxalaticus]
ATGACGCGCGGCACGCACGCGAAGCGTCTCGACCTGTGGATGAACGGCTTGCCGGTGGGTCACTGGGAAACCGCGCCCGC
CGGCGACCGGCTGGCCTATCGCGAAGACTGGATTGCCGACCCGCAAGGCCGGCCGCTGTCCTTGTCATTGCCCTTTACGC
CGGGCAACCAGCCACACCGCGGACCGGTAGTCGCCAACTATTTCGACAACCTGCTGCCCGACAGCGATGCCATCAGGCGG
CGCATCGCGGCCCGGTATCAGACCGGCGGGACCGACGCCTTCGCGCTGCTGGCCAGGCTCGGCCGCGACTGCGCCGGCGC
CCTGCAGATGCTGCCGCCGCAGGAAGCGCCGATGGCGTTGAAGCGCGTCCAGGGCCGCCCGCTGTCGGAGACGGAGATCG
CCACCCTGCTGCACGAGGCCACGGCCGAGCCCGTGCTCGGGCTGCGCGAGCCTATCGATGACCTGCGCCTGTCAATTGCC
GGCGCACAGGAAAAGACCGCGCTGCTGCGCTGGGACGGGCAATGGCTGTTGCCGCAAGGCAGTACGCCGACCACGCATAT
CTTCAAGCTGCCCATGGGACTGGTGGGCAATATGCGCGCCGACATGCGGACCTCGGTGGAAAACGAATGGCTCTGCGCCA
GGATCGTCGCCGCGTTTGGCCTGCCGGTCGCTGCCTGCGAGATCGCCCGCTTCGGGGATACCAAGGCGCTGGTCGTCGAA
CGCTTCGACCGCAAGCCCTCGGCAGACGGTTCCTGGCTGCTGCGCCTGCCGCAGGAAGACATGTGCCAGGCCACCGGGAC
GTCGGCATTGCAGAAGTACGAGTCGGACGGCGGGCCTGGCATCCAGCAGATCGCAGACATCCTCTCGGGCTCGCGCTCGG
CGCTGTCCGATCGCCGCAACTTCTTCCTCGCGCAGATCGTCTTCTGGCTGCTCGCGGCCACGGATGGACATGGCAAGAAC
TTCAGCATCAGCCACCTGCCGGGCAGCCGATATGAGGCGACGCCGCTGTATGACATCCTGTCGGCGCATCCGATCATCGG
CAAAGGCAAGAACCAGGTGGCGCCGCAACGGGCCCGGCTGGCGATGGCGTTGCACGGCAAGAATTCGCACTACGCCATCC
AGGAGATCCAGCGGCGGCACTGGTTTGCCCAGGGACAGCGCATCGGCTTCTCGCCCGACGATGTCGAGTCGATGCTCGAC
GAGGTCATGTCGCAGACCAGCCGGGCTATCGACGCCGCCGCTTCCGCGCTGCCGCCGGAATTCCCCATGGACCTGGCCGA
TGCGATCTTCGATGGCATGCGCCGGCAGCAGCGGCGCCTGGCCGCCTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT158763 WP_003214273.1 NZ_CP054136:549023-549304 [Bacillus altitudinis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp

>AT158763 NZ_CP069810:c1849468-1849088 [Cupriavidus oxalaticus]
ATGCACTATTCCATCCAGACACTCAGCCAGTTGCGGCCGATCCTGCAGGGCTTCCGGAAGTCCAGGGGCCTGACGCAGGC
AAATATGGCGGCTTACCTCGGCGTCAGGCAGCAGACCTATGCCGAACTGGAAGCCAACCCTGCCGCGGCCAGCGTAGAGC
GGCTGTTCAAGGCGCTGCGCGTGCTGGGCGTGGAGATGGTCCTTTCCCCTGCTCCAGATACCGCCATGCAGCCGGAACCG
GAGCCTCCTTCCGGCTCCGTGACGCCGCCGGAAAAGGATCCGCGCCGGGCTACACAGGAAGAACAGCCGAAAATGCCCGC
GAAGCGCAAGGCAAGCCGCACCGCCCTCGAGACCGGTCAGCCAAAGCGGGAGGACTGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K2MHT4

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References