158759

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4625199..4625787 Replicon chromosome
Accession NZ_CP054129
Organism Citrobacter portucalensis strain BY9F36

Toxin (Protein)


Gene name PumA Uniprot ID A0A5B0T4T9
Locus tag HRV88_RS22050 Protein ID WP_032942059.1
Coordinates 4625199..4625516 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A5B0STC7
Locus tag HRV88_RS22055 Protein ID WP_032942057.1
Coordinates 4625509..4625787 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRV88_RS22030 (HRV88_21970) 4620969..4621793 + 825 WP_003031641.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
HRV88_RS22035 (HRV88_21975) 4621862..4623085 + 1224 WP_235125871.1 L-sorbose 1-phosphate reductase -
HRV88_RS22040 (HRV88_21980) 4623087..4623899 + 813 WP_153753899.1 shikimate 5-dehydrogenase -
HRV88_RS22045 (HRV88_21985) 4624384..4624935 + 552 WP_008786891.1 AAA family ATPase -
HRV88_RS22050 (HRV88_21990) 4625199..4625516 + 318 WP_032942059.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRV88_RS22055 (HRV88_21995) 4625509..4625787 + 279 WP_032942057.1 putative addiction module antidote protein Antitoxin
HRV88_RS22060 (HRV88_22000) 4625898..4626587 + 690 WP_032942056.1 dipeptidase PepE -
HRV88_RS22065 (HRV88_22005) 4626754..4628385 - 1632 WP_003031618.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(3-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11993.00 Da        Isoelectric Point: 9.6790

>T158759 WP_032942059.1 NZ_CP054129:4625199-4625516 [Citrobacter portucalensis]
IMEILQTMVFRRWEQNLRDRRAKTLIATRLFRLANGLAGDVKPVGEGVSEMRISYGPGYRIYFKQQGCRIIILLCGGDKS
SQANDITLAKMLARTLDSQEIFCHE

Download         Length: 318 bp

>T158759 NZ_CP069799:c2536284-2536018 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATGATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9872.45 Da        Isoelectric Point: 5.8233

>AT158759 WP_032942057.1 NZ_CP054129:4625509-4625787 [Citrobacter portucalensis]
MNKLTHYDPATALVDDEEIAVFMADALETGDAAYIAKALGVVARAKGMANIAAETGLSREQLYRSFSEKGNPTLKTTLAV
MKVLGIELTLKK

Download         Length: 279 bp

>AT158759 NZ_CP069799:c2536541-2536284 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B0T4T9

Antitoxin

Source ID Structure
AlphaFold DB A0A5B0STC7

References