Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3661416..3662036 Replicon chromosome
Accession NZ_CP054129
Organism Citrobacter portucalensis strain BY9F36

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HRV88_RS17615 Protein ID WP_002892050.1
Coordinates 3661818..3662036 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag HRV88_RS17610 Protein ID WP_003021733.1
Coordinates 3661416..3661790 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRV88_RS17600 (HRV88_17550) 3656562..3657755 + 1194 WP_032942549.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HRV88_RS17605 (HRV88_17555) 3657778..3660927 + 3150 WP_008783964.1 efflux RND transporter permease AcrB -
HRV88_RS17610 (HRV88_17560) 3661416..3661790 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
HRV88_RS17615 (HRV88_17565) 3661818..3662036 + 219 WP_002892050.1 HHA domain-containing protein Toxin
HRV88_RS17620 (HRV88_17570) 3662218..3662769 + 552 WP_003835924.1 maltose O-acetyltransferase -
HRV88_RS17625 (HRV88_17575) 3662886..3663356 + 471 WP_063941318.1 YlaC family protein -
HRV88_RS17630 (HRV88_17580) 3663435..3663575 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
HRV88_RS17635 (HRV88_17585) 3663577..3663837 - 261 WP_008783961.1 type B 50S ribosomal protein L31 -
HRV88_RS17640 (HRV88_17590) 3664026..3665579 + 1554 WP_071692491.1 EAL domain-containing protein -
HRV88_RS17645 (HRV88_17595) 3665631..3665984 - 354 WP_048226278.1 DUF1428 family protein -
HRV88_RS17650 (HRV88_17600) 3666049..3666678 - 630 WP_071445860.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T158756 WP_002892050.1 NZ_CP054129:3661818-3662036 [Citrobacter portucalensis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T158756 NZ_CP069799:c2211566-2211462 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT158756 WP_003021733.1 NZ_CP054129:3661416-3661790 [Citrobacter portucalensis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT158756 NZ_CP069799:2211369-2211407 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References