Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3661416..3662036 | Replicon | chromosome |
Accession | NZ_CP054129 | ||
Organism | Citrobacter portucalensis strain BY9F36 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | HRV88_RS17615 | Protein ID | WP_002892050.1 |
Coordinates | 3661818..3662036 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | R8WZW8 |
Locus tag | HRV88_RS17610 | Protein ID | WP_003021733.1 |
Coordinates | 3661416..3661790 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HRV88_RS17600 (HRV88_17550) | 3656562..3657755 | + | 1194 | WP_032942549.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
HRV88_RS17605 (HRV88_17555) | 3657778..3660927 | + | 3150 | WP_008783964.1 | efflux RND transporter permease AcrB | - |
HRV88_RS17610 (HRV88_17560) | 3661416..3661790 | + | 375 | WP_003021733.1 | Hha toxicity modulator TomB | Antitoxin |
HRV88_RS17615 (HRV88_17565) | 3661818..3662036 | + | 219 | WP_002892050.1 | HHA domain-containing protein | Toxin |
HRV88_RS17620 (HRV88_17570) | 3662218..3662769 | + | 552 | WP_003835924.1 | maltose O-acetyltransferase | - |
HRV88_RS17625 (HRV88_17575) | 3662886..3663356 | + | 471 | WP_063941318.1 | YlaC family protein | - |
HRV88_RS17630 (HRV88_17580) | 3663435..3663575 | - | 141 | WP_005125190.1 | type B 50S ribosomal protein L36 | - |
HRV88_RS17635 (HRV88_17585) | 3663577..3663837 | - | 261 | WP_008783961.1 | type B 50S ribosomal protein L31 | - |
HRV88_RS17640 (HRV88_17590) | 3664026..3665579 | + | 1554 | WP_071692491.1 | EAL domain-containing protein | - |
HRV88_RS17645 (HRV88_17595) | 3665631..3665984 | - | 354 | WP_048226278.1 | DUF1428 family protein | - |
HRV88_RS17650 (HRV88_17600) | 3666049..3666678 | - | 630 | WP_071445860.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T158756 WP_002892050.1 NZ_CP054129:3661818-3662036 [Citrobacter portucalensis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T158756 NZ_CP069799:c2211566-2211462 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14427.23 Da Isoelectric Point: 5.5653
>AT158756 WP_003021733.1 NZ_CP054129:3661416-3661790 [Citrobacter portucalensis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
Download Length: 375 bp
>AT158756 NZ_CP069799:2211369-2211407 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | R8WZW8 |