Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2571386..2572122 Replicon chromosome
Accession NZ_CP054129
Organism Citrobacter portucalensis strain BY9F36

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HRV88_RS12430 Protein ID WP_234102858.1
Coordinates 2571640..2572122 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag HRV88_RS12425 Protein ID WP_008784769.1
Coordinates 2571386..2571652 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRV88_RS12405 (HRV88_12380) 2566438..2567625 + 1188 WP_032943450.1 outer membrane protein transport protein -
HRV88_RS12410 (HRV88_12385) 2567863..2568492 + 630 WP_008784772.1 winged helix-turn-helix transcriptional regulator -
HRV88_RS12415 (HRV88_12390) 2568609..2568995 - 387 WP_008784771.1 hypothetical protein -
HRV88_RS12420 (HRV88_12395) 2569250..2571232 + 1983 WP_235123739.1 alkyl sulfatase dimerization domain-containing protein -
HRV88_RS12425 (HRV88_12400) 2571386..2571652 + 267 WP_008784769.1 DUF1778 domain-containing protein Antitoxin
HRV88_RS12430 (HRV88_12405) 2571640..2572122 + 483 WP_234102858.1 GNAT family N-acetyltransferase Toxin
HRV88_RS12435 (HRV88_12410) 2572420..2573607 - 1188 WP_079934034.1 outer membrane protein transport protein -
HRV88_RS12440 (HRV88_12415) 2573700..2574815 - 1116 WP_235123741.1 DUF4056 domain-containing protein -
HRV88_RS12445 (HRV88_12420) 2574816..2575928 - 1113 WP_235123753.1 BamA/TamA family outer membrane protein -
HRV88_RS12450 (HRV88_12425) 2575946..2576884 - 939 WP_008784763.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(80-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17639.49 Da        Isoelectric Point: 9.7819

>T158755 WP_234102858.1 NZ_CP054129:2571640-2572122 [Citrobacter portucalensis]
VGFVTAPEPLTHIHQLAEFVSGEIVLDDWLKQKGLKNQALGAARTFVVCKTDTRKVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSVRGKGLGADLLYDAVLRCYKVAENIGVRAVMVHALTDEAKRFYLHHGFKASQLQERTLFLRLS

Download         Length: 483 bp

>T158755 NZ_CP069799:c2154601-2154392 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10159.65 Da        Isoelectric Point: 4.6558

>AT158755 WP_008784769.1 NZ_CP054129:2571386-2571652 [Citrobacter portucalensis]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIEMLDAPVAEDPAIRKLL
ARKPQWDL

Download         Length: 267 bp

>AT158755 NZ_CP069799:c2154906-2154613 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References