Detailed information of TA system TA158738

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1222533..1224132
• Replicon: chromosome
• Accession: NZ_CP054125
• Organism: Bordetella pertussis strain NZ3

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: Q7VVM6
• Locus tag: HRJ57_RS06050
• Protein ID: WP_003816876.1
• Coordinates: 1222792..1224132 (+)
• Length: 447 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HRJ57_RS06045
• Protein ID: WP_019247974.1
• Coordinates: 1222533..1222790 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRJ57_RS06030 (HRJ57_06010)	1218196..1218807	-	612	WP_010931041.1	DUF2239 family protein	-
HRJ57_RS06035 (HRJ57_06015)	1219030..1220490	+	1461	WP_003812368.1	IMP dehydrogenase	-
HRJ57_RS06040 (HRJ57_06020)	1220587..1222179	+	1593	WP_010931040.1	glutamine-hydrolyzing GMP synthase	-
HRJ57_RS06045 (HRJ57_06025)	1222533..1222790	+	258	WP_019247974.1	helix-turn-helix transcriptional regulator	Antitoxin
HRJ57_RS06050 (HRJ57_06030)	1222792..1224132	+	1341	WP_003816876.1	type II toxin-antitoxin system HipA family toxin	Toxin
HRJ57_RS06055 (HRJ57_06035)	1224228..1224917	-	690	WP_010931038.1	TetR/AcrR family transcriptional regulator	-
HRJ57_RS06060 (HRJ57_06040)	1224930..1226360	+	1431	WP_019247976.1	MFS transporter	-
HRJ57_RS06065 (HRJ57_06045)	1226592..1227670	+	1079	Protein_1201	tellurite resistance/C4-dicarboxylate transporter family protein	-
HRJ57_RS06070 (HRJ57_06050)	1228103..1228906	+	804	WP_019248072.1	IclR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (10-112)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-70)

Sequences

Toxin

Protein

• Length: 447 a.a.
• Molecular weight: 49632.79 Da
• Isoelectric Point: 7.4158

>T158738 WP_003816876.1 NZ_CP054125:1222792-1224132 [Bordetella pertussis]
MGRRSHSRSLSIWTNGVRVGRWTVPARGEMELQYDVDWVRADVGRPLSLSLPFNLQNLPLKGERVANYFDNLLPDSDAIR
RRVAERFRTGSVDPFDLLKAIGRDCVGAVQILEDEEIPEGFDRIEGVPLSEEDIERHLIETVTPRAFAAGRDPDADFRIS
LAGAQEKTAFLWWGGQWLAPRGATSTSHIFKLPLGLVGGRRADFSTSVDNEWLCLKLLKAYGLDVAEASIATFGQQRVLV
VERFDRRVAPNGQWLMRLPQEDFCQVEGCSPLRKYENEGGPGLKALFATLRQSVNAAVDMRTLMAAQILFWLLRAPDGHA
KNFSIQLLPRGRFQLTRLYDVMSAYPVLGDGANQWSPFEIKLAMALIGKNRHYEMHGIQRRHFNSTAQKVGYGPTAEPII
EDLLARTPAIIAAVQADLPQDFSPRVADSVLGGLAQAAKSLGAMMP

Nucleotide

• Length: 1341 bp

>T158738 NZ_CP069798:54598-54858 [Paralysiella testudinis]
ATGCAGCACCGTTTCACCGCATCGGCAGCCGAAGATTTCCAGTATTGGATGAAACATGATCAAAAGAAAGTTGAACGCAT
CAAAATACTGGTGGCCGACATCAAACAAAACCATCCGCGCGGCATTGGCAAACCGGAGCCGTTAAAACATCAAAAACAGG
GCTTATGGTCGCAGCGGATAGACCGAGAACACCGCTTAGTGCATGCGATCGAGGATCGCATACTCACCATTTATGCCTGC
CGTTTTCATTATGGCAAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 8815.04 Da
• Isoelectric Point: 7.1642

>AT158738 WP_019247974.1 NZ_CP054125:1222533-1222790 [Bordetella pertussis]
MPPPSQPLLTTGQLGAVLQAARKAQGLTQSALASRIGLSQSRVSHLELNAHQLSVEQLLAWCAALGLELTIATRGSPAGS
SDADW

Nucleotide

• Length: 258 bp

>AT158738 NZ_CP069798:54338-54586 [Paralysiella testudinis]
GTGGATAAAGTAATCTCTTATACCAGCGTGCGCGAAAACTTGGCACAAGTTATGAACGATGTGTGCAATGACAAAATCAT
TACCCACATTACCCGCCGTAATGGCGAAAACTGTGTTTTGATGTCGGAAGAAGAATATATGTCTATGTGCGAAACACTGT
ACTTGTTCGGCAACCCGGCAAATGCACGCCATCTGGAAAAATCGCTTCAGGAAGCGGAAGAAGGCAAGTTTGTGCAGATT
GACTTGTGA

Structures

Toxin

• AlphaFold DB: Q7VVM6