Detailed information of TA system TA158737

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2747260..2748859
• Replicon: chromosome
• Accession: NZ_CP054123
• Organism: Bordetella pertussis strain NZ6

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: Q7VVM6
• Locus tag: HRJ60_RS13285
• Protein ID: WP_003816876.1
• Coordinates: 2747260..2748600 (-)
• Length: 447 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HRJ60_RS13290
• Protein ID: WP_019247974.1
• Coordinates: 2748602..2748859 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRJ60_RS13265 (HRJ60_13200)	2742486..2743289	-	804	WP_019248072.1	IclR family transcriptional regulator	-
HRJ60_RS13270 (HRJ60_13205)	2743722..2744800	-	1079	Protein_2606	tellurite resistance/C4-dicarboxylate transporter family protein	-
HRJ60_RS13275 (HRJ60_13210)	2745032..2746462	-	1431	WP_019247976.1	MFS transporter	-
HRJ60_RS13280 (HRJ60_13215)	2746475..2747164	+	690	WP_010931038.1	TetR/AcrR family transcriptional regulator	-
HRJ60_RS13285 (HRJ60_13220)	2747260..2748600	-	1341	WP_003816876.1	type II toxin-antitoxin system HipA family toxin	Toxin
HRJ60_RS13290 (HRJ60_13225)	2748602..2748859	-	258	WP_019247974.1	helix-turn-helix transcriptional regulator	Antitoxin
HRJ60_RS13295 (HRJ60_13230)	2749213..2750805	-	1593	WP_010931040.1	glutamine-hydrolyzing GMP synthase	-
HRJ60_RS13300 (HRJ60_13235)	2750902..2752362	-	1461	WP_003812368.1	IMP dehydrogenase	-
HRJ60_RS13305 (HRJ60_13240)	2752585..2753196	+	612	WP_010931041.1	DUF2239 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (10-112)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-70)

Sequences

Toxin

Protein

• Length: 447 a.a.
• Molecular weight: 49632.79 Da
• Isoelectric Point: 7.4158

>T158737 WP_003816876.1 NZ_CP054123:c2748600-2747260 [Bordetella pertussis]
MGRRSHSRSLSIWTNGVRVGRWTVPARGEMELQYDVDWVRADVGRPLSLSLPFNLQNLPLKGERVANYFDNLLPDSDAIR
RRVAERFRTGSVDPFDLLKAIGRDCVGAVQILEDEEIPEGFDRIEGVPLSEEDIERHLIETVTPRAFAAGRDPDADFRIS
LAGAQEKTAFLWWGGQWLAPRGATSTSHIFKLPLGLVGGRRADFSTSVDNEWLCLKLLKAYGLDVAEASIATFGQQRVLV
VERFDRRVAPNGQWLMRLPQEDFCQVEGCSPLRKYENEGGPGLKALFATLRQSVNAAVDMRTLMAAQILFWLLRAPDGHA
KNFSIQLLPRGRFQLTRLYDVMSAYPVLGDGANQWSPFEIKLAMALIGKNRHYEMHGIQRRHFNSTAQKVGYGPTAEPII
EDLLARTPAIIAAVQADLPQDFSPRVADSVLGGLAQAAKSLGAMMP

Nucleotide

• Length: 1341 bp

>T158737 NZ_CP069797:c2062393-2062028 [Actinobacillus pleuropneumoniae]
ATGGATACCAATGTACGACAATGGTTAGCAACGATTAAACCGAGTCAGACGAATATTAGCTGTATCACGCTTTCCGAAAT
AAAAACGGGGATTTTACTCAAAGCTCGTAAAGATCCTATTCAAGCCGAGCGGTTAAATCATTGGTTTACCCATAATGTAT
TAAGCGTTTATCAAGCTAAATCCTTTTCTATAAATAATGAAATTGCGTTACTGGCTTCTGAATACCACATTCCAAATAAA
ATGGATTTAAACGATGCTTATATTGCCGCAACCGCTAAATATCATAATTTAGTGCTTGTTACTCGTAATTTGAAAGACTT
CAACCGTTGCGATATACGTTTATTTAATCCTTTCGAACCGAATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 8815.04 Da
• Isoelectric Point: 7.1642

>AT158737 WP_019247974.1 NZ_CP054123:c2748859-2748602 [Bordetella pertussis]
MPPPSQPLLTTGQLGAVLQAARKAQGLTQSALASRIGLSQSRVSHLELNAHQLSVEQLLAWCAALGLELTIATRGSPAGS
SDADW

Nucleotide

• Length: 258 bp

>AT158737 NZ_CP069797:c2062743-2062456 [Actinobacillus pleuropneumoniae]
ATGCCAATTACTATTACCTCTCGAGAATTTAATCAACACGCCAGTAAAGTGCTGAAAATGGCAGAAAAAGAACCGGTTTT
TATCACTAAATGGGGAAAAATTGTCAGCGTTGTCTCCAATTATGTTGATTACAAACAGCACACAACGGTTGAGCCTAGCT
TTGAAGAACTATTTGCCTCATCTACGGATGAATCGGTTAGCGATGAGTTTTGGCAAGATTTTGAACAGACATTAACAAAA
ATTCGCAAAAGTAATAAATCCGAACAAATAGATTTTGGAGATGAATAA

Structures

Toxin

• AlphaFold DB: Q7VVM6