Detailed information of TA system TA158704

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2750438..2752037
• Replicon: chromosome
• Accession: NZ_CP054104
• Organism: Bordetella pertussis strain NZ26

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: Q7VVM6
• Locus tag: HRJ80_RS13295
• Protein ID: WP_003816876.1
• Coordinates: 2750438..2751778 (-)
• Length: 447 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HRJ80_RS13300
• Protein ID: WP_019247974.1
• Coordinates: 2751780..2752037 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRJ80_RS13275 (HRJ80_13205)	2745664..2746467	-	804	WP_019248072.1	IclR family transcriptional regulator	-
HRJ80_RS13280 (HRJ80_13210)	2746900..2747978	-	1079	Protein_2607	tellurite resistance/C4-dicarboxylate transporter family protein	-
HRJ80_RS13285 (HRJ80_13215)	2748210..2749640	-	1431	WP_019247976.1	MFS transporter	-
HRJ80_RS13290 (HRJ80_13220)	2749653..2750342	+	690	WP_010931038.1	TetR/AcrR family transcriptional regulator	-
HRJ80_RS13295 (HRJ80_13225)	2750438..2751778	-	1341	WP_003816876.1	type II toxin-antitoxin system HipA family toxin	Toxin
HRJ80_RS13300 (HRJ80_13230)	2751780..2752037	-	258	WP_019247974.1	helix-turn-helix transcriptional regulator	Antitoxin
HRJ80_RS13305 (HRJ80_13235)	2752391..2753983	-	1593	WP_010931040.1	glutamine-hydrolyzing GMP synthase	-
HRJ80_RS13310 (HRJ80_13240)	2754080..2755540	-	1461	WP_003812368.1	IMP dehydrogenase	-
HRJ80_RS13315 (HRJ80_13245)	2755763..2756374	+	612	WP_010931041.1	DUF2239 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (10-112)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-70)

Sequences

Toxin

Protein

• Length: 447 a.a.
• Molecular weight: 49632.79 Da
• Isoelectric Point: 7.4158

>T158704 WP_003816876.1 NZ_CP054104:c2751778-2750438 [Bordetella pertussis]
MGRRSHSRSLSIWTNGVRVGRWTVPARGEMELQYDVDWVRADVGRPLSLSLPFNLQNLPLKGERVANYFDNLLPDSDAIR
RRVAERFRTGSVDPFDLLKAIGRDCVGAVQILEDEEIPEGFDRIEGVPLSEEDIERHLIETVTPRAFAAGRDPDADFRIS
LAGAQEKTAFLWWGGQWLAPRGATSTSHIFKLPLGLVGGRRADFSTSVDNEWLCLKLLKAYGLDVAEASIATFGQQRVLV
VERFDRRVAPNGQWLMRLPQEDFCQVEGCSPLRKYENEGGPGLKALFATLRQSVNAAVDMRTLMAAQILFWLLRAPDGHA
KNFSIQLLPRGRFQLTRLYDVMSAYPVLGDGANQWSPFEIKLAMALIGKNRHYEMHGIQRRHFNSTAQKVGYGPTAEPII
EDLLARTPAIIAAVQADLPQDFSPRVADSVLGGLAQAAKSLGAMMP

Nucleotide

• Length: 1341 bp

>T158704 NZ_CP069712:3492329-3492547 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 8815.04 Da
• Isoelectric Point: 7.1642

>AT158704 WP_019247974.1 NZ_CP054104:c2752037-2751780 [Bordetella pertussis]
MPPPSQPLLTTGQLGAVLQAARKAQGLTQSALASRIGLSQSRVSHLELNAHQLSVEQLLAWCAALGLELTIATRGSPAGS
SDADW

Nucleotide

• Length: 258 bp

>AT158704 NZ_CP069712:3491929-3492303 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAGTATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: Q7VVM6