Detailed information of TA system TA158695

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2742452..2744051
• Replicon: chromosome
• Accession: NZ_CP054087
• Organism: Bordetella pertussis strain NZ44

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: Q7VVM6
• Locus tag: HRJ98_RS13285
• Protein ID: WP_003816876.1
• Coordinates: 2742452..2743792 (-)
• Length: 447 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HRJ98_RS13290
• Protein ID: WP_019247974.1
• Coordinates: 2743794..2744051 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRJ98_RS13265 (HRJ98_13180)	2737678..2738481	-	804	WP_019248072.1	IclR family transcriptional regulator	-
HRJ98_RS13270 (HRJ98_13185)	2738914..2739992	-	1079	Protein_2605	tellurite resistance/C4-dicarboxylate transporter family protein	-
HRJ98_RS13275 (HRJ98_13190)	2740224..2741654	-	1431	WP_019247976.1	MFS transporter	-
HRJ98_RS13280 (HRJ98_13195)	2741667..2742356	+	690	WP_010931038.1	TetR/AcrR family transcriptional regulator	-
HRJ98_RS13285 (HRJ98_13200)	2742452..2743792	-	1341	WP_003816876.1	type II toxin-antitoxin system HipA family toxin	Toxin
HRJ98_RS13290 (HRJ98_13205)	2743794..2744051	-	258	WP_019247974.1	helix-turn-helix transcriptional regulator	Antitoxin
HRJ98_RS13295 (HRJ98_13210)	2744405..2745997	-	1593	WP_010931040.1	glutamine-hydrolyzing GMP synthase	-
HRJ98_RS13300 (HRJ98_13215)	2746094..2747554	-	1461	WP_003812368.1	IMP dehydrogenase	-
HRJ98_RS13305 (HRJ98_13220)	2747777..2748388	+	612	WP_010931041.1	DUF2239 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2720879..2761262	40383

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (10-112)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-70)

Sequences

Toxin

Protein

• Length: 447 a.a.
• Molecular weight: 49632.79 Da
• Isoelectric Point: 7.4158

>T158695 WP_003816876.1 NZ_CP054087:c2743792-2742452 [Bordetella pertussis]
MGRRSHSRSLSIWTNGVRVGRWTVPARGEMELQYDVDWVRADVGRPLSLSLPFNLQNLPLKGERVANYFDNLLPDSDAIR
RRVAERFRTGSVDPFDLLKAIGRDCVGAVQILEDEEIPEGFDRIEGVPLSEEDIERHLIETVTPRAFAAGRDPDADFRIS
LAGAQEKTAFLWWGGQWLAPRGATSTSHIFKLPLGLVGGRRADFSTSVDNEWLCLKLLKAYGLDVAEASIATFGQQRVLV
VERFDRRVAPNGQWLMRLPQEDFCQVEGCSPLRKYENEGGPGLKALFATLRQSVNAAVDMRTLMAAQILFWLLRAPDGHA
KNFSIQLLPRGRFQLTRLYDVMSAYPVLGDGANQWSPFEIKLAMALIGKNRHYEMHGIQRRHFNSTAQKVGYGPTAEPII
EDLLARTPAIIAAVQADLPQDFSPRVADSVLGGLAQAAKSLGAMMP

Nucleotide

• Length: 1341 bp

>T158695 NZ_CP069712:1829708-1829959 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 8815.04 Da
• Isoelectric Point: 7.1642

>AT158695 WP_019247974.1 NZ_CP054087:c2744051-2743794 [Bordetella pertussis]
MPPPSQPLLTTGQLGAVLQAARKAQGLTQSALASRIGLSQSRVSHLELNAHQLSVEQLLAWCAALGLELTIATRGSPAGS
SDADW

Nucleotide

• Length: 258 bp

>AT158695 NZ_CP069712:1829956-1830210 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCTCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Toxin

• AlphaFold DB: Q7VVM6