Detailed information of TA system TA158671

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2747992..2749591
• Replicon: chromosome
• Accession: NZ_CP054072
• Organism: Bordetella pertussis strain NZ59

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: Q7VVM6
• Locus tag: HRK13_RS13315
• Protein ID: WP_003816876.1
• Coordinates: 2747992..2749332 (-)
• Length: 447 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HRK13_RS13320
• Protein ID: WP_019247974.1
• Coordinates: 2749334..2749591 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRK13_RS13295 (HRK13_13220)	2743218..2744021	-	804	WP_019248072.1	IclR family transcriptional regulator	-
HRK13_RS13300 (HRK13_13225)	2744454..2745532	-	1079	Protein_2612	tellurite resistance/C4-dicarboxylate transporter family protein	-
HRK13_RS13305 (HRK13_13230)	2745764..2747194	-	1431	WP_019247976.1	MFS transporter	-
HRK13_RS13310 (HRK13_13235)	2747207..2747896	+	690	WP_010931038.1	TetR/AcrR family transcriptional regulator	-
HRK13_RS13315 (HRK13_13240)	2747992..2749332	-	1341	WP_003816876.1	type II toxin-antitoxin system HipA family toxin	Toxin
HRK13_RS13320 (HRK13_13245)	2749334..2749591	-	258	WP_019247974.1	helix-turn-helix transcriptional regulator	Antitoxin
HRK13_RS13325 (HRK13_13250)	2749945..2751537	-	1593	WP_010931040.1	glutamine-hydrolyzing GMP synthase	-
HRK13_RS13330 (HRK13_13255)	2751634..2753094	-	1461	WP_003812368.1	IMP dehydrogenase	-
HRK13_RS13335 (HRK13_13260)	2753317..2753928	+	612	WP_010931041.1	DUF2239 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (10-112)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-70)

Sequences

Toxin

Protein

• Length: 447 a.a.
• Molecular weight: 49632.79 Da
• Isoelectric Point: 7.4158

>T158671 WP_003816876.1 NZ_CP054072:c2749332-2747992 [Bordetella pertussis]
MGRRSHSRSLSIWTNGVRVGRWTVPARGEMELQYDVDWVRADVGRPLSLSLPFNLQNLPLKGERVANYFDNLLPDSDAIR
RRVAERFRTGSVDPFDLLKAIGRDCVGAVQILEDEEIPEGFDRIEGVPLSEEDIERHLIETVTPRAFAAGRDPDADFRIS
LAGAQEKTAFLWWGGQWLAPRGATSTSHIFKLPLGLVGGRRADFSTSVDNEWLCLKLLKAYGLDVAEASIATFGQQRVLV
VERFDRRVAPNGQWLMRLPQEDFCQVEGCSPLRKYENEGGPGLKALFATLRQSVNAAVDMRTLMAAQILFWLLRAPDGHA
KNFSIQLLPRGRFQLTRLYDVMSAYPVLGDGANQWSPFEIKLAMALIGKNRHYEMHGIQRRHFNSTAQKVGYGPTAEPII
EDLLARTPAIIAAVQADLPQDFSPRVADSVLGGLAQAAKSLGAMMP

Nucleotide

• Length: 1341 bp

>T158671 NZ_CP069709:c4148634-4148461 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 8815.04 Da
• Isoelectric Point: 7.1642

>AT158671 WP_019247974.1 NZ_CP054072:c2749591-2749334 [Bordetella pertussis]
MPPPSQPLLTTGQLGAVLQAARKAQGLTQSALASRIGLSQSRVSHLELNAHQLSVEQLLAWCAALGLELTIATRGSPAGS
SDADW

Nucleotide

• Length: 258 bp

>AT158671 NZ_CP069709:c4148958-4148662 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: Q7VVM6