Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 87653..88563 Replicon plasmid pSWHvKp
Accession NZ_CP054064
Organism Klebsiella pneumoniae strain WSHvKP

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag HQ868_RS25225 Protein ID WP_004026354.1
Coordinates 87653..88123 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag HQ868_RS25230 Protein ID WP_004026357.1
Coordinates 88120..88563 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQ868_RS25205 82663..83061 - 399 WP_004212796.1 H-NS histone family protein -
HQ868_RS25210 83398..83892 - 495 WP_004212794.1 thermonuclease family protein -
HQ868_RS25215 84070..85019 + 950 Protein_87 DUF1173 family protein -
HQ868_RS25220 86405..87102 - 698 Protein_88 IS1 family transposase -
HQ868_RS25225 87653..88123 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
HQ868_RS25230 88120..88563 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
HQ868_RS25235 88664..89167 - 504 Protein_91 DUF4113 domain-containing protein -
HQ868_RS25240 89265..89486 - 222 WP_004213643.1 DUF2188 domain-containing protein -
HQ868_RS25245 89631..89786 - 156 WP_004213642.1 hypothetical protein -
HQ868_RS25250 89861..91987 - 2127 WP_004213640.1 TonB-dependent receptor family protein -
HQ868_RS25255 92074..93027 - 954 Protein_95 fec operon regulator FecR -
HQ868_RS25260 93024..93545 - 522 WP_004213635.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroB / iroC / iroD / iroN / rmpA / rmpA2 / iutA / iucD / iucC / iucB / iucA 1..211588 211588
- flank IS/Tn - - 86405..86908 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T158654 WP_004026354.1 NZ_CP054064:c88123-87653 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T158654 NZ_CP069709:181663-181770 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTTGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT158654 WP_004026357.1 NZ_CP054064:c88563-88120 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT158654 NZ_CP069709:c181614-181551 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References