Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4558394..4558910 Replicon chromosome
Accession NZ_CP054063
Organism Klebsiella pneumoniae strain WSHvKP

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag HQ868_RS22115 Protein ID WP_009309309.1
Coordinates 4558394..4558678 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HQ868_RS22120 Protein ID WP_002886901.1
Coordinates 4558668..4558910 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQ868_RS22090 4553878..4554186 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
HQ868_RS22095 4554271..4554444 + 174 WP_002886906.1 hypothetical protein -
HQ868_RS22100 4554447..4555190 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HQ868_RS22105 4555547..4557685 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
HQ868_RS22110 4557926..4558390 + 465 WP_047718307.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HQ868_RS22115 4558394..4558678 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HQ868_RS22120 4558668..4558910 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HQ868_RS22125 4558988..4560898 - 1911 WP_004152270.1 BglG family transcription antiterminator -
HQ868_RS22130 4560921..4562075 - 1155 WP_047718309.1 lactonase family protein -
HQ868_RS22135 4562142..4562882 - 741 WP_173424254.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T158651 WP_009309309.1 NZ_CP054063:c4558678-4558394 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T158651 NZ_CP069707:c3833207-3832809 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT158651 WP_002886901.1 NZ_CP054063:c4558910-4558668 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT158651 NZ_CP069707:c3833503-3833210 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References